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Myocardial tactile stiffness

Research Project

Project/Area Number 09671364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

TANAKA Makoto (1999)  University of Tokyo, Dept of Cardiothoracic Surg., M., 医学部・附属病院, 助手 (60302684)

田中 修 (1997-1998)  東京大学, 医学部・附属病院, 助手 (30251309)

Co-Investigator(Kenkyū-buntansha) MIYAJI Kagami  University of Tokyo, Dept. of Cardiothoracic Surg., M., 医学部・附属病院, 助手 (40281703)
IMANAKA Kazuto  University of Tokyo, Dept of Cardiothoracic Surg., M., 医学部・附属病院, 助手 (80282672)
TANAKA Osamu  University of Tokyo, Dept of Cardiothoracic Surg., M., 医学部・附属病院, 助手 (30251309)
OHTSUKA Toshiya  University of Tokyo, Dept. of Cardiothoracic Surg., M., 医学部・附属病院, 助手 (80262004)
末松 義弘  東京大学, 医学部・附属病院, 医員
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordstactile sensor / myocardial stiffness / myocardial function / 触覚センサー / 局所心筋機能 / 心筋の硬さ / Langendorf潅流 / stiffness / 心筋
Research Abstract

Background. Evaluation of regional myocardial contractile function is of clinical importance. We have developed a new tactile sensor system for accurate measurement of myocardial stiffness in situ. We found that thc myocardial stiffness measured by this sensor, which we call tactile stiffness, can be a very useful index for accurate quantification of regional myocardial function. In this study, we used a coronary stenosis model to investigate regional myocardial tactile stiffness under conditions of reduced coronary blood flow.
Methods. The myocardial tactile stiffness, coronary blood flow, and ventricular pressure and volume, of five open chest mongrel dogs weighing 15 to 17 kg, were measured. After measuring the baseline myocardial stiffness, coronary arterial stenosis was induced with a balloon occluder.
Results. Reducing the coronary flow to 50% and 25% of the baseline level reduced the end-systolic tactile stiffness significantly from 2.20 ± 0.16 g/mm2 to 2.05 ± 0.20 g/mm2 (p < 0.05) and from 2.21 ± 0.16 g/mm2 to 1.96 ± 0.18 g/mm2 (p < 0.01), respectively. Reducing the flow, to 50% and 25%, increased the end-diastolic stiffness significantly from 1.29 ± 0.15 g/mm2 to 1.39 ± 0.14 g/mm2 (p < 0.01) and from 1.30 ± 0.16 g/mm2 to 1.46 ± 0.14 g/mm2 (p < 0.05), respectively. Conclusions. We consider that the regional myocardial tactile stiffness will be a useful index sensitive enough to detect changes in regional contractile function under conditions of reduced, coronary blood flow.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report

Research Products

(12 results)

All Other

All Publications (12 results)

  • [Publications] Miyaji, K.: "Myocardial tactile stiffness during acute reduction of coronary blood flam"Aunals of Thoracic Surgery. 69. 151-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakajima, J.: "Transthoracoscopic needle biopsy for indeterminate lung nodules"Surg. Endosc.. 13. 386-9 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyaji, K.: "Myocardial tactile stiffness: a variable of regional myocardial function"Journal of American College of Cardiology. 31. 1165-73 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyaji, K.: "Regional myocardial stiffness measured by a new tactile sensor system"Japanese Heart Journal. 38. 709-15 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyaji, K.: "The stiffness of lymphonodes containing lung carcinoma metastases"Cancer. 80. 1920-5 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohtsuka, T.: "New tactile sensor techniques for localization of pulmonary nodules"Int. Surg.. 82. 12-4 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyaji K, Sugiura S, Inaba H, Takamoto S, Omata S.: "Myocardial tactile stiffness during acute reduction of coronary blood flow."Ann Thorac Surg.. 69. 151-155 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakajima J, Furuse A, Kohno T, Ohtsuka T, Matsumoto J, Oka T.: "Transthoracoscopic needle biopsy for indeterminate lung nodules."Surg Endosc.. 13. 386-389 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyaji K, Sugiura S, Omata S. Kaneko Y. Ohtsuka T. Takamoto S.: "Myocardial tactile stiffness : a variable of regional myocardial function."J Am Coll Cardiol.. 31. 1165-1173 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyaji K, Furuse A, Kaneko Y, Ohtsuka T, Sugiura S, Omata S.: "Regional myocardial stiffness measured by a new tactile sensor system."Jpn Heart J.. 38. 709-715 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyaji K, Furuse A, Nakajima J, Kohno T, Ohtsuka T, Yagyu K, Oka T, Omata S.: "The stiffness of lymph nodes containing lung carcinoma metastases : a new diagnostic parameter measured by a tactile sensor."Cancer.. 80. 1920-1925 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohtsuka T, Furuse A, Kohno T, Nakajima J, Yagyu K. Omata S.: "New tactile sensor techniques for localization of pulmonary nodules."Int Surg.. 82. 12-14 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary

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Published: 1997-03-31   Modified: 2016-04-21  

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