| Project/Area Number |
09671369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Toyama Medical and Pharmaceutical University |
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Principal Investigator |
SUGIYAMA Shigeki Toyama Medical and Pharmaceutical University, branch hospital, lector, 附属病院, 講師 (90201574)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUTI Toshiyuki Toyama Medical and Pharmaceutical University, MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (20242498)
小山 信二 富山医科薬科大学, 医学部, 助手 (10215428)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Thoracoscope / Tracheal anastomosis / stapler / Metastatic pulmonary tumor / Microwave / Lung cancer / Model of metastatic lung cancer / Thoracoscopic cutting needle biopsy |
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| Research Abstract |
(1) We assessed an application of a skin stapler for tracheal anastomosis experimentally in dogs. Sections of cervical trachea covering 5 rings from 2.4 cm to 3.5 cm in length were excised and anastomosis was performed by skin stapler in group 1 (n= 10) and by resorbable 4-0 suturing in group 2(n= 10). After 6 months, all animals harvested and observed anastomotic site macroscopically and microscopically. Histological examination of the anastomotic sites in all animals revealed normal tracheal epithelium covering. Tracheal anastomosis by stapler is possible and the same as hand-sewn in the short-term experimentally.
(2) The safety and efficacy of video-assisted thoracoscopic surgery (VATS) for metastatic lung disease was study retrospectively. Between January 1993 and December 1996, we performed pulmonary wedge resection by VATS for metastatic lung tumors in twenty-one patients (19 male, 10 female : A group). Between January 1987 and January 1990, we performed pulmonary wedge resection on 21 patients (14 male, 7 female : Open group) with metastatic pulmonary disease via a middle sternal-splitting approach or lateral thoracotomy. Median survival was 28.9 months for the Open group and 37.9 months for the VATS group. Actuarial survival was not significantly different for the two groups. Thus the type of approaches did not affect survival following metastasectomy.
(3) A microwave generator and delivery system for metastatic pulmonary tumor was designed. Using this probe for pulmonary tumor was easy to controlled coaglation form lung parenchyema.
(4) Pericutaneous cutting needle biopsy under the thoracoscope were presented. This thoracoscopic cutting needle biopsy was easy to obtain a specimen for the frozened section diagnosis. Under the view of thoracoscope, pericutaneous cuting needle biospy is safty, saving the cost for staples and easy to control the bleeding from the lung.
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