| Project/Area Number |
09671381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
SANO Shunji OKAYAMA UNIVERSITY MEDICAL SCHOOL, PROFESSOR, 医学部, 教授 (50235438)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | non-heart-beating donor / heart transplantation / reperfusion / cardiac function / 移植 / 心臓移植 / Emax |
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| Research Abstract |
We attempted to establish a method to utilize the non-beating heart. [Methods] A total of thirteen dogs were used in this study. Cardiac arrest was induced by exsanguination. The hearts were left in situ at room temperature for 60 minutes. Then the hearts were excised and reperfused in the ex-vivo perfusion apparatus, similar to the Langendorff apparatus. The hearts were tested whether they could keep ejecting in the apparatus against 80 mmHg of afterload with 10 mmHg of preload and then transplanted orthotopically. [Results] Fore of 13 hearts could keep ejecting in the apparatus, and they showed good hemodynamics (systolic arterial pressure > 80 mmHg with mean left atrial pressure < 10 mmHg) without dopamine after transplantation. However the other 9 hearts could not keep ejecting in the apparatus. Only 6 of these hearts could be weaned from cardiopulmonary bypass, but could not keep good hemodynamics without dopamine. [Conclusion] Donor heart function evaluated in the perfusion apparatus well predict the post-transplant donor heart function prior to orthotopic heart transplantation. Moreover, the former showed comparable systolic function with pre-cardiac arrest value. Our method could be useful in selection of transplantable hearts in the non-heart-beating donors.
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