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A study about total pulmonary replacement with artificial implantable lung.

Research Project

Project/Area Number 09671382
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOkayama University

Principal Investigator

SHIMIZU Nobuyoshi  Okayama University, Medical School, Professor, 医学部, 教授 (90108150)

Co-Investigator(Kenkyū-buntansha) AOE Motoi  Okayama University, Medical Hospital, Assistant, 医学部附属病院, 助手 (80260660)
ICHIBA Shingo  Okayama University, Medical Hospital, Assistant, 医学部附属病院, 助手 (30284102)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsArtificial lung / Pulmonary replacement / Pulmonary assist / Right heart failure / Pulmonary artery banding / Canine model / Artificial device / Oxygen supply / 実験 / 体内植込み / 完全置換 / 肺高血圧 / 体内植え込み
Research Abstract

At present, RVAD is commonly used for a right ventricular failure (RVF). In clinic, RVF patients usually suffer poor gas exchange due to cardiac failure. The purpose of this study is whether pumpless ECMO in right ventricle (RY) to left atrium (LA) bypass could be useful as a means of a treatment for a chronic RYF.Experiment I.Ten mongrel dogs (2.5-6.0 kg, mean 3.9kg) were performed banding of the main pulmonary artery (mPA), aimed for RVF due to pulmonary hypertension. A pressure study of the right heart was performed after a long term raising (97-205 days, mean 160 days). All the cases showed the mean RY pressure (m-RVP) [mmHg]<greater than or equal>20 (average 30.2*9
Experiment II.Implantation of the artificial lung (MENOX EL2000, Kuraray Co. Japan) was performed between RY outlet and LA for ten of the RVF model. As we lost one animal during operation, nine (4.8-8.4kg, mean 6.5kg) were used to evaluate the gas transfer and the cardiac function. All the cases showed the m-RVP (average 20.7+4.2 mmHg) after the RV-LA bypass was equal to the preoperative value or dropped, and the average cardiac function tended to be improved. Experiment III.After experiment II, the nine dogs were performed ligation of mPA and total RV-LA bypass was started. Five (4.8*8.4kg, mean 6.6kg) of nine RVF model were supported over 6 hours and evaluated the gas transfer and cardiac function (group 1), while the other four died soon after ligation of mPA due to RVF.Five non-PA banding mongrels with the membrane oxygenator were used as control (Group II). Group I, as well as Group II, showed good gas transfer rates, averages of 32.5*8.3m1/min. of 02 and 37.2*11.6m1/min, of CO2 with a blood flow rate of 0.68*0.19 L/min..
A partial bypass between RV-LA with the commercially available membrane oxygenator provides better recovary of RVF than a total bypass in RYF model.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 為季清和 外: "MENOXTMEL2000による人工肺植込みの実験的検討" Membrene Artificial Lung. 21. 56-60 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamesue K., Ichiba S., Aoe M., Kawai T., Yamamoto H., Nawa S., Shimizu N., Tanaka S.: "An experimental study about implantation of artificial lung with MENOX EL 2000" Membrene Artificial Lung. 21. 56-60 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 為季清和: "MENOX^<TM>EL2000による人工肺植え込みの実験的検討" 膜型肺. 21号. (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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