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Development of vascular protheses for a child-expansion after long term implantation

Research Project

Project/Area Number 09671388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKYOTO PREFECTURAL UNIVERSITY OF MEDICINE

Principal Investigator

SATOH Shinichi  SATOH,Shinichi, 医学部, 講師 (30178735)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordspercutaneous angioplasty / neointimal formation / 経皮的血管形成術(PTCA)
Research Abstract

Vascular prostheses implanted in growing children may cause serious hemodynamic disturbance, when they become too small in diameter comparing to the grown native arteries. We have developed vascular prostheses which can be dilated by a percutaneous transluminal angioplasty (PTA) at a given time to compensate such discrepancy in diameter. The prosthesis was made of woven polyester fiber fabrics, the circumferential yarns of which consist of two different types of polyester fiber bundles. We have reported that the prostheses were successfully dilated with the use of PTA balloon in vitro and in the short term animal experiment as well. In this study, the prostheses with the initial diameter of 6mm were implanted to descending thoracic aortae (8-10mm in diameter) of mongrel dogs for 18 months as a longer term evaluation. After 18 month-implantation, with the use of PTA ballooning of 15 ATM, implanted grafts were dilated to 9mm in diameter which was maintained after 30 days. No bleeding, hematoma or pseudo-aneurysmal formation were observed. In conclusion, the newly developed grafts could be safely dilated after implantation in vivo.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (1 results)

All Other

All Publications (1 results)

  • [Publications] 増田慎介, 土井潔, 神田圭一, 佐藤伸一, 和田行雄, 岡隆弘: "拡張可能な小児用人工血管-移植後長期における拡張性について-"人工臓器. Vol.28:1. 268-272 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary

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Published: 1997-04-01   Modified: 2016-04-21  

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