| Project/Area Number |
09671397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health (1999)
Tokyo Women's Medical University (1997-1998) |
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Principal Investigator |
HACHIDA Mitsuhiro Department of Second Surgery, University of Occupational and Environmental Health, Associate Professor, 医学部, 助教授 (00167587)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMATSU Takashi Department of Second Surgery, University of Occupational and Environmental Health, Associate, 医学部, 助手 (70279339)
YANO Kouichi Department of Second Surgery, University of Occupational and Environmental Health, Assistant Professor, 医学部, 講師 (80258615)
大加戸 彰彦 東京女子医科大学, 医学部, 助手 (10281403)
野々山 真樹 東京女子医科大学, 医学部, 助手 (40201701)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Cardiomyopathy / Volume reduction therapy / Oxygen consumption / Wallstress / Heart Transplant / Artificial Heart / Batista Operation |
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| Research Abstract |
Abstract
Mechanical circulatory assist and ventricular volume reduction therapy, so called Batista operation, has been widely used as a bridge to transplantation. However, Since 1996 clinical trial for Novacor assist device has started. Since 1996, two patients have undergone Novacor implantation. One patient was supported by the device for 6 months and then received heart transplantation at UCLA. Another patients has been doing well for 2 months under Novacor device. The institute that underwent Novacor implantation is still limited number. By contrast Batista operation is widely applicable in Japan. In this study, the effect of volume reduction was assessed by experimental model.
Using rabbit model, heart was excised and connected to Langendorf apparatus. The heart was arrested for 6 hours using cardioplegia and was recovered following the ischemic time. The small elastic balloon was inserted to the left ventricle and inflated upto 200% of normal volume, reducing to 100% of normal volume. During the inflation, left ventricular function such as developed pressure, left ventricular wall stress and oxygen consumption were measured. The wall stress and oxygen consumption was significantly reduced at 140% of normal left ventricular volume. These data indicated that left ventricular volume reduction therapy can be accomplished at 140% of normal left ventricular volume.
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