• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of neurotrophic factor for cerebral ischemia

Research Project

Project/Area Number 09671426
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionEhime University

Principal Investigator

KUMON Yoshiaki  Ehime University, School of Medicine, Associate Professor, 医学部, 助教授 (80127894)

Co-Investigator(Kenkyū-buntansha) OHUE Shiroh  Ehime University Hospital, Assistant Professor, 医学部附属病院, 講師 (70213626)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordscerebral ischemia / neurotrophic factor / growth associated protein-43 / water maze test / thalamus / ciliary neurotrophic factor / regeneration / 脳虚血 / 神経栄養因子 / 脳高次機能 / 神経再生 / 毛様体神経栄養因子 / 視床
Research Abstract

We evaluated the mechanism and the effect of neurotrophic factor on neuronal death in the ipsilateral thalamus following cortical infarction using the focal isehemia model of stroke-prone spontaneously hypertensive rats.
(I) Slowly' progressive neuronal death which showed accumulation of calcium and decreased protein synthesis 3 and 5 days after ischemia was observed in the ipsilateral thalamus. This change was prevented by intraventricular administration of a protein synthesis inhibitor. The mechanism of neuronal death was considered to be apoptosis. (2) Growth-associated protein (GAP)-43, which is ta marker of the regenerated axons, was recognized 3 days after ischemia in the ipsilateral thalamus, and the axons from the spinal trigeminal nucleus or medial fascicular fibers were considered to be GAP-43 positive structures. These axons were decreased in number following ciliary neurotrophic factor (CNTF) intraventricular continuous administration. (3) Following CNTF iniraventricular administration during 4 weeks after isehemia, neuronal death in the ipsilateral thalamus as well as cortical infarction were prevented. Furthermore, the spatial learning ability studied by the Morris water maze test was preserved 2 and 4 weeks after isehemia.
In conclusion, the neurotrophic factor prevented neurorial death in the ipsilateral thalanius, and preserved the spatial learning ability following focal cerebral isehemia.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Watanabe H.,Kumon Y.,et al.: "Protein synthesis inhibitor transiently reduces neuronal death in the thalamus of spontaneously hypertensive rats following cortical infarction" Neuroscience Letters. 233. 25-28 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Watanabe H.,Kumon Y.,et al.: "Changes in protein synthesis and calcium homeostasis in the thalamus of spontaneously hypertensive rats with focal cerebral ischemia" Journal of Cerebral Blood Flow and Metabolism. 18. 686-696 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kumon Y.,et al.: "Transient increase in the expression of growth associated protein-43 in the thalamus of spontaneously hypertensive rats with cortical infarction" Biomedical Research. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Watanabe H., Kumon Y., et al.: "Protein synthesis inhibitor transiently reduces neuronal death in the thalamus of spontaneously hypertensive rats following cortical infarction." Neuroscience Letters. 233. 25-28 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Watanabe H., Kumon Y., et al.: "Changes in protein synthesis and calcium homeostasis in the thalamus of spontaneously hypertensive rats with focal cerebral ischemia." Journal of Cerebral Blood Flow and Metabolism. 18. 686-696 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kumon Y., et al.: "Transient increase in the expression of growth-associated protein-43 in the thalamus of spontaneously hypertensive rats with cortical infarction." Biomedical Research. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Watanabe H.,Kumon Y.,et al.: "Protein synthesis inhibitor transiently reduces neuronal death in the thalamus of spontaneously hypertensive rats following cortical infarction" Neuroscience Letters. 233. 25-28 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Watanabe H.,Kumon Y.,et al.: "Changes in protein synthesis and calcium homeostasis in the thalamus of spontaneously hypertensive rats with focal cerebral ischemia" Journal of Cerebral Blood Flow and Metabolism. 18. 686-696 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kumon Y.,et al.: "Transient increase in the expression of growth associated protein-43 in the thalamus of spontaneously hypertensive rats with cortical infarction" Biomedical Research. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Watanabe H., Kumon Y.et al.: "Protein synthesis inhibitor transiently reduces neuronal death in the thalamus of SH-SP rats following cortical infarction." Neuroscience Letters. 233. 25-28 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Watanabe H., Kumon Y.et al.: "Changes in protein synthesis and calcium homeostasis in the thalamus of SH-SP rats with focal cerebral ischemia" Journal of Cerebral Blood Flow and Metabolism. (in press). (1997)

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi