| Project/Area Number |
09671429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Saga Medical School |
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Principal Investigator |
MINETA Toshihiro Saga Medical School, Faculty of Medicine, Instructor, 医学部, 助手 (20264187)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Kouzou Saga Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (60238516)
TABUCHI Kazuo Saga Medical School, Faculty of Medicine, Professor, 医学部, 教授 (50116480)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | CNS development / differential display / glial differentiation / neural differentiation / neuron / oligodendrocyte / astrocyte / VASP / gial differetiation / oligo dendrocyte / Neuronal development / Qlial development / Differential display / Ena / VASP protein family / dipperential display / neuronal development / glial development |
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| Research Abstract |
We have used the differential display method to identify genes which are differentially expressed during CNS development. Using this approach, we have identified a novel rat cDNA (RNB6) that codes for a protein of 42 kDa and is expressed in the developing embryonic rat brain. The level of expression of RNB6 peaks on postnatal day 1 in brain tissue and gradually decrease thereafter. The predicted aminoacid sequence of RNB6 shares a 45% homology with the human actin-associated protein, vasodilator-stimulated phosphoprotein (VASP). VASP functions as a lignad for profilin, a signal-transducer for actin filament assembly. The shared homology of RNB6 and VASP suggests that RNB6 may take part in cellular motility during development of the CNS.
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