• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Experimental attempt for the recovery of damaged spinal cord

Research Project

Project/Area Number 09671440
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOsaka City University Medical School

Principal Investigator

HAKUBA Akira  Osaka City University Medical School, Department of Neurosurgery, Professor, 医学部, 教授 (10047011)

Co-Investigator(Kenkyū-buntansha) SATO Makoto  Fukui Medical University, Department of Anatomy (2), Professor, 医学部, 教授 (10222019)
TAKAGI Hiroshi  Osaka City University Medical School, First Department of Anatomy, Professor, 医学部, 教授 (30163174)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsspinal cord / corticospinal tract / pyramidal tract / axon / microglia / recovery / blood-brain-barrier / 脊髄損傷 / 橋 / 再生 / 神経再生
Research Abstract

The basilar pons plays an important role in the establishment of the corticopontine projection by releasing a diffusible molecule which induces and directs collateral branchings along the carticospinal axon shafts. We have attempted to apply this nature of pons-derived diffusible factor that enhances the sprouting of cortical axons and controls their growth direction to recovery the damaged cortical axons in the spinal cord. Before applying this potential pons-derived factor, we need to identify and clone the responsible pons factor(s). Then, we modified the mRNA differential display to search for genes expressed differentially in the basilar pons during the formation of the corticopontine projection to identify the authentic and/or pans-related molecules.
Results we have obtained so far are as follows :
(1) Three gene fragments which are potentially the pontine-derived molecules have been identified. Full- length cDNA clones of two candidate fragments have been obtained.
(2) In addition to the experiments mentioned above, we tried to utilize the nature of some kind of microglial cells that can enter the brain through the blood-brain-barrier (Sawada et al., ). Since the microglial cells tend to accumulate around the injured site, it is ideal to employ the microglial cells that deliver the neurotrophic factor(s) which enhances the neuron survival/axon repair. We reconfirm the ability of some kind of micraglial cells of entering into the brain. We still in the process of searching for the efficient method of generating, genetically modified microglial cells.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Ohata,K.,et al: "Posterior approach for cervical intramedullary arteriovenous malformation." J.Neurosurg.(印刷中). (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohata,K.,et al.: "Efficacy of indwed hypoteusion in swgical treatment of large carrenous sinus caverncna." J.Neurosurg.(印刷中). (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohata,K.,et al.: "Occulusion of the sigmoid sinus after sugery ria the presigmcidal-transpetrosal approach" J.Neurosurg.89. 575-584 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takami,T.,et al.: "ldentifying mRNAs inrolued potentially in corticopontire projection by modified differential display." Osaka City Medical Journal. 44. 17-33 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohata,K.,et al.,: "Craniotoncy repair with titanium miniplates" J.Clin,Nourosa.5. 81-86 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishikawa,M.et al.: "Multiple appearing and varnishing aneurysms: primary augitis of the central nervous system." J Neurosury.88. 133-137 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohata,K.et.al.: "Creative Techniques in Neurosurgery" Churchill Livingstone (印刷中), (印刷中

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohata,K.,etal.,: "Operetire Neurosurgical Techniques" Churchill Livingstone (印刷中), (印刷中

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yagi, T., Ohata, K., Hapue, M.and Hakuba A.: "Intramedullary spinal cord tumour associated with neurofibromatosis type 1" Acta Neurochir (Wien) (1997). 139. 1055-1060 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakamoto, H.and Kitano., Yasui, T., Komiyama, M., Nishikawa, M., Iwai, Y., Yamanaka, K., Nakajima, H.and Kishi, H., Kan, M., Fujitani, K., Hakuba, A.: "Direct extracranial-intracranical bypass for children with Moyamoya disease" Clinical Neurology and Neurosurgery. 99. s128-s133 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishikawa, M., Sakamoto, H., Hakuba, A.and Nakanishi, N., Inoue, Y.: "Pathogenesis of Chiari malformation : a morphometric sudy of the posterior cranial fossa" J.Neurosurg.86. 40-47 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuyuguchi, N.and Hakuba, A., Okamura, T.and Ochi, H., Suzuki, T., Sunada, I: "PET for diagnosis of malignant lymphoma of the scalp : comparison of [11C] methy-L-methionine and [18F] fluoro-2-deoxyglucos" Journal of Computer Assisted Tomography. 21. 590-593 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, T.Hakuba, A.and Ohata, K.: "Sub-occipital cranioplasty for Chiari malformation (expansive sub-occipital cranioplasty with dural plasty)" 11th International Congress of Neurological Surgery. 1483-1489 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishikawa, M., Sakamoto, H., and Nishimura, Katuyama, J., and Hakuba, A.: "Multiple appearing and vanishing aneurysms : primary angiitis of the central nervous system" Journal of Neurosurgery. 88. 133-137 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tada, T., Minakuchi, K., Koda, M., Kozuka, T., Inoue, Y., Nishita, T., and Hakuba, A., Nakajima, Oniyama, Y.: "Patterns of Recurrence after Complete Remission with Definitive Radiotherapy on the Treatment of Malignant Glioma" International Journal of Clinical Oncology. 3. 36-40 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishio, A., Nishijima, Y., and Hakuba, A.: "Spontaneous occlusion of the traumatic middle meningeal arteriovenous fistula : A case report" Journal of Neurovascular Disease. 3, No.2. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohata, K., Hapue, M., Tsuruno, T., Mosino, M., Branco Soares, S, Jr.and Hakuba, A.: "Craniotomy repair with titanium miniplates" Journal of Clinical Neuroscience. 5. 81-86 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka K, Kim A, Naruse H, Hakuba A: "The effect of experimental spinal cord edema on the spinalevoked potential" Acta Neurochir (Wien) (1998). suppl1, 71. 101-103 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takami, T., and Hakuba, A., Yoneda, T., Nagano, T., Takagi, H., and Sato, M.: "Identifying mRNAs Involved Potentially in corticopontine projection by Modified Differential Display" Osaka City Medical Journal. 44. 17-33 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Ohata, S.Nunta-aree, M.Morino, N.Tsuyuguchi, M.Haque, Y.Inoue, H.Ogura, A.Hakuba: "Aetiology of delayed facial palsy after vestibular schwannoma surgery : clinical data and hypothesis" Acta Neurochir (Wien). 140. 913-917 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Ohata, M.Haque, M.Morino, K.Nagai, A.Nishio, Y.Nishijima, A.Hakuba: "Occlusion of the sigmoid sinus after surgery via the presigmoidal-transpetrosal approach" J Neurosurg. 89. 575-584 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Ohata, A.El-Naggar, T.Takami, M.Morino, Y.El-Adawy, K.El-Sheik, Y.Inoue, A.Hakuba: "Efficacy of induced hypotension in surgical treatment of large cavemous sinus cavemoma" J Neurosurg. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Ohata, T.Takami, K.El-Bahy, M.Morino, M.Maeda, Y.Inoue, A.Hakuba: "Surgical outcome of intramedullary spinal cord ependymoma" Acta Neurochir (Wien). (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Ohata, T.Takami, A.El-Naggar, M.Morino, A.Nishio, A.Inoue, A.Hakuba: "Posterior approach for cervical intramedullary arteriovenous malformation with diffuse type nidus" J Neurosurg. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Ohata, A.Hakuba: Extended middle fossa approach, in R.F.Speztler (ed) : Oerative Techniques in Neurosurgery. New York : Churchill Livingstone (in press), (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Ohata, A.El-Naggar, T.Takami, A.Hakuba: Orbiotozygomatic infratemporal approach for parasellar meningiomas, in H.H.Schmidek (ed) : Operative Neurosurgical Techniues. 4th edition. New York : Churchill Livingstone (in press), (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohata,K.,et al: "Posterior approach for cervical intramedullary arteriovenous malformation." J.Neurosurg.印刷中.

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohata,K.,et al.: "Efficacy of induced hypotension in surgical treatment of large carvenous sinus cavernoma." J.Neurosurg.印刷中.

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohata,K.,et al.: "Occulusion of the sigmoid sinus after surgery via the presigmcidal-transpetrosal approach" J.Neurosurg.89. 575-584 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takami,T.,et al,: "Identifying mRNAs involued potentially in corticopontine projection by modified differential display." Osaka City Medical Journal. 44. 17-33 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohata,K.,et al.,: "Craniotomy repair with titanium miniplates" J.Clin.Neurosci.5. 81-86 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishikawa,M.et al.: "Multiple appearing and varishing aneurysms:primary angiitis of the central nerrous system." J.Neurosurg.88. 133-137 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohata,K.et.al.: "Creative Techniques in Neurosurgery" Churchill Livingstone, (印刷中

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohata,K.,et al.: "Operatire Neurosurgical Techniques" Churchill Livingstone, (印刷中

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagano,T.: "Differentially expressed clfactomedin-related glycoproteins(Pancortins)in the brain." Mol.Brain Res.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Takami,T.: "Medification of mRNA differential display:identification of mRNAs which are differentially express in the basilar pons during the formation of the certicopotine projection." Osaka City Medical Journal. (in press).

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi