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Immunohistochemical and molecular-biological studies of microcystic meningiomas.

Research Project

Project/Area Number 09671441
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOsaka Prefecture University

Principal Investigator

TSUNODA Shigeru  Osaka Prefecture University, College of Integrated Arts and Sciences, Professor, 総合科学部, 教授 (60163862)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsmicrocystic meningioma / arachnoid trabecular cell / glutathione S-transferase-pi(GST-pi) / arachnoid trabecular cell / immunohistochemistry / melecular biology / restriction landmark genomic scannin / aracnoid trabecular cell
Research Abstract

We proposed in 1989 the view that the microcystic meningioma represents differentiation into arachnoid trabecular cells, on the grounds that microcystic meningioma cells resemble arachnoid trabecular cells which support the normal subarachnoid space. We reported in 1995 that glutathione S-transferase-pi (GST-pi) is immunohistochemically positive in arachnoid trabecular cells of normal arachnoid villi and of microcystic meningiomas.
The present study by restriction landmark genomic scanning (RLGS) revealed an alteration on chromosome 16q where E-cadherin gene is located. And arachnoid trabecular cells were found to be positive for E-cadherin in normal arachnoid villi and microcystic meningiomas. E-cadherin is thought to play a role in the differentiation of meningiomas into microcystic components.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Tsuzuki T et al: "Tumor cell proliferation and apoptosis associated with the gamma knife effect." Stereotact Funct Neurosurg. 66. 39-48 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al: "Retinoblastoma protein expression and MIB-1 correlate with survival of patients with with malignant astrocytoma." Cancer. 80. 242-249 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsunoda S et al: "Clinicopathological study of meningioangiomatosis." International Congress of Neurosurgical Surgery. 11. 483-487 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al: "Genomic alterations in human glioma cell lines detected by restriction landmark genomic scanning." Journal of Neuro-Oncology. 34. 203-209 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yabuno T et al: "Drag resistance and apoptosis in ENU-induced rat brain tumors treated with anti-cancer drugs." Journal of Neuro-Oncology. 36. 105-112 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al: "Genetic variations in recurrent astrocytic tumors detected by restriction landmark genomic scaning." Brain Tumor Pathol. 15. 1-6 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuzuki T et al.: "Tumor cell proliferation and apoptosis associated with the gamma knife effect." Stereotact Funct Neurosurg. 66. 39-48 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujioka M et al.: "Haemangioma calcificans presenting as intracranial haemorrhages during pregnancy." J Clin Neuroscience. 4. 234-236 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al.: "Retinoblastom protein expression and MIB-1 correlate with survival of patients with with malignant astrocytoma." Cancer. 80. 242-9 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsunoda S et al.: "Clinicopathological study of meningioangiomatosis." International Congress of Neurosurgical Surgery. 11. 483-487 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al.: "Genomic alterations in human glioma cell lines detected by restriction landmark genomic scanning." Journal of Neuro-Oncology. 34. 203-209 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al.: "Analyses of human gliomas by restriction landmark genomic scanning." Journal of Neuro-Oncology. 35. 113-120 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al.: "Genomic alterations human gliomas detected by restriction landmark genomic scanning." Brain Tumor Pathol. 14. 13-17 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yabuno T et al.: "Drag resistance and apoptosis in ENU-induced rat brain tumors treated with anti-cancer drugs." Journal of Neuro-Oncology. 36. 105-112 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hori Y et al.: "Combined effects of hyperthermic treatment and doxorubicin hydrochloride on killing mouse leukemic cells." Jpn J Hyperthermic Oncol. 14. 251-257 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inui T et al.: "Immunohistochemical parameters in relation to genetic alterations in maningiomas." Neuroimmunological Research. 11. 18-24 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura M et al.: "Genetic variations in recurrent astrocytic tumors detected by restriction landmark genomic scanning." Brain Tumor Pathol. 15. 1-6 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yabuno T: "Drugresistance and apoptosis in ENU-induced rat brain tumors treated with anti-cancer drugs" J Neuro-Oncol. 36. 105-112 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakamura M: "Genetic variation in astrocytic tumors detected by restriction landmark genomic scanning" Brain Tumor Pathol. 15. 1-6 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hori Y: "Combined effect of hypertherthermic treatment and doxorubicin hyudrochloride on killing mouse leukemic ceIIs" Jpn J Hyperthermic Oncol. 14. 251-257 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakamura M: "Genomic alterations of human gliomas detected by restriction landmark genomic scanning." Brain Tumor Pathology. 14. 13-17 (199)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura M: "Analyses of human gliomas by restriction landmark genomic scanning." Journal of Neuro-Oncology. 35. 113-120 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura M: "Genomic alterations in human glioma cell lines detected by restriction landmark genomic scanning." Journal of Neuro-Oncology. 34. 203-209 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tsunoda S: "Clinicopathological study of meningioangiomatosis." 11th International Congress of Neurological Surgery ed by Monduzzi Editore,Bologna. 483-487 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura M: "Retinoblastoma protein expression and MIB-1 correlate with survival of patients with malignant astrocytoma." Cancer. 80. 242-249 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fujioka M: "Haemangioma calcificans presenting as intracranial haemorrhages during pregnancy." J Clin Neuroscience. 4. 234-236 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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