| Project/Area Number |
09671447
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Saitama Medical School |
|---|
Principal Investigator |
NISHIKAWA Ryo Assoc. Prof., Saitama Medical School, 医学部, 助教授 (90237678)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥3,000,000 (Direct Cost: ¥3,000,000)
|
|---|
| Keywords | Knock-out mouse / TP53 / brain tumor / ethylnitrosourea / 神経膠腫 |
|---|
| Research Abstract |
Brain tumor induction in p53 knock-out mice by transplacental exposure to ethylnitrosourea (ENU) was attempted. Three out of 80 (4%) p53(+/-) mice and one of 10 (10%) p53(-/-) mice who prenatally exposed to ENU developed brain tumors. Mice #400 and #505, both of whom are p53(+/-), developed brain tumor (possibly schwannoma) when they are about 30 weeks old. Mice #537(p53[-/-]) and #370 (p53[+/-]) developed gliomas at about 10 weeks old. We should need to increase the incidence of brain tumor induction.
|
