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Neuronal Control of Cerebrovascular Bed : Role of Basal Forebrain

Research Project

Project/Area Number 09671449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionJUNTENDO UNIVERSITY

Principal Investigator

MAEDA Minoru  Juntendo Univ. , Neurosurgery, Professor, 医学部, 教授 (40101430)

Co-Investigator(Kenkyū-buntansha) MORI Kentaro  Juntendo Univ. , Neurosurgery, Assistant Professor, 医学部, 助教授 (30200364)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsCerebrovascular Bed / Cholinergic Basal Forebrain / Nitric Oxide / NOS inhibitor / Basalocortical Neurovascular Pathway / Cerebral Hypothermia / Cerebral Perfusion Pressure / Relative Ischemia / ICP / CBV / Intracortical NO neuron / NO / Hypothermia / CBF / CMRO2 / Misery Perfusion / Vasopressor / Cholinerigic Basal Forebrain / Single Neuron Activity / Compression Ischemia / Mild Hypothermia / CMRO_2 / Glutamate
Research Abstract

I] Control of ICP and the Cerebrovascular Bed by the Cholinergic Basal Forebrain
-role of basalocortical neurovascular pathway via the intracortical Nitric Oxide neurons-
Previously, we reported the function of central noradrenergic cell groups, the cholinoceptive pontine area and the cholinergic basal forebrain (BF) in the generation of plateau waves. This study investigated the involvement of the basalcortical neurovascular pathway and intracortical nitric oxide (NO) neurons in the control of ICP and the cercbrovascular bed.
Twenty cats anesthetized and immobilized with chloralose with kaolin-induced hydrocephalus were used for the experiments. ICP, BP and ETCO_2 were continuously monitored. CBF and NO in the brain tissue were also measured continuously using a Laserflo and electrochemical NO electrodes, respectively.
Microinjection of glutamte or Ach into the dorsomedial hypothalamic nucleus (DMH) of the cats produced persistent increases in ICP and CBF and a decrease in BP.ETCO_2 conce … More ntration changed little.
The Bring rate of the DMH -single neuron discharge increased in phase with increased ICP.
NO concentration and CBV were increased in phase with the plateau phase during spontaneous "A" wave. NO and CBV were. also increased or decreased depending on the rising phase or the falling phase of ICP during repeated plateau wave like ICP variations elicited by microinjection of glutamate into the DMH.NO concentration increased considerably in the ipsilateral frontal and parietal lobes associated with increased ICP and increased CBV in response to microinjection of Ach into the DMH.A potent inhibitor of nitric oxide syntheses (L-NAME) reduced these Ach-elicited in ICY, conical CBV and NO.
The cholinergic BF might contribute to he regulation of the cerebrovascular bed, The present observations suggest gut participation of NO in the mediation of the BF elicited increased ICP and CBV, and indicate the involvement of at least a neuronal source of NO, as the intracortical NOS neurons that innervate local microvessels appear to be regulated by BF neurons.
II] Misery Perfusion Caused by Cerebral Hypothermic -Cerebrovascular Bed and NO Concentrations-.
Therapeutic cerebral hypothermia is widely used for the treatment of severe head injury and cerebral ischemia. The effects of cerebral hypothermia on the cerebral blood flow (CBF) and metabolism, and cerebral vasculature in the normal brain were investigated. CBF, CBV, AVDO_2, CMRO_2, and CVR were momitored during cerebral hypothermia in 24 anesthetized cats.
Hypothemia may cause vasoconstriction, low NO concentration, and misery perfusion in the brain blow 31℃. This potential risk of relative ischemia can be avoided by combination with vasopressor administration.
The cerebral ischemic parameters were also evaluated during he rewarming period to determine the critical cerebral perfusion pressure (CPP) threshold to avoid ischemic deterioration.
A CPP of 60mmHg during the rewarming period causes irreversible ischemia, which indicates continuation of cerebral vasoconstriction. Therefore, a higher CPP (>90mmHg) is required to avoid cerebral ischemia dung the rewarming period. Less

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] M.Maeda,M.Miyazaki: "Control of ICP and The Cerebrovascular Bed By the Basalocortical Neurovascular Pathway via The Intracortical NO neurons"ICP 2000-Intracranial Pressure and Brain Monitoring. 223 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Aoki,K.Mori,M.Maeda: "Appropriate Cerebral Perlusion Pressure During The Rewarming Period From Therapeutic Hypothermia"ICP 2000-Intracranial Pressure and Brain Monitoring. 117 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori,M.Maeda: "Misery perfusion caused by cerebral hypothermia improved by vasopressor administration"Neurological Research. 21. 585-59 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori,M.Maeda: "Effects of Mild and Moderate Hypothermia on Cerebral Metabolism and Glutamate in an Experimental Head Injury"Acta Neurochirurgica. 71. 222-224 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Maeda: "Control of ICP and the Cerebrovascular Bed by the Cholinergic Basal Forebrain"Acta Neurochirurgica. 71. 293-296 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori,M.Maeda: "Mechanism of ^<201> Thallium-chioride uptake in tumor cells and its relationship to potassium channels"Neurological Research. 20. 19-22 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori,K.Cho,M.Maeda: "Thallium-201 Single Photon Emission Computed Tomography imaging of Meningioma Cells in Hyperostosis"Neurol Medico-chirurgica. 37. 594-599 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kentaro Mori,Minoru Maeda: "Use of [^3H] methylglucose and [^<14>C] iodoantipyrine to determine kinetic parameters of glucose transport in rat brain"Am.J.Physiol. R163-R171 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Maeda, M.Miyazaki: "Control of ICP and The Cerebrovascular Bed By the Basalocortical Neurovascular Pathway via The Intracortical NO neurons"ICP 2000-Intracranial Pressure and Brain Monitoring. 223 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Aoki, K.Mori, M.Maeda: "Appropriate Cerebral Perfusion Pressure During The Rewarming Period From Therapeutic Hypothermia"ICP2000-Intracranial Pressure and Brain Monitoring. 117 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori, M.Maeda: "Misery perfusion caused by cerebral hypothermia improved by vasopressor administration"Neurological Research. 21. 585-592 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori, M.Maeda: "Effects of Mild and Moderate Hypothermia on Cerebral Metabolism and Glutamate in an Experimental Had Injury"Acta Neurochirurgica. 71. 222-224 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Maeda: "Control of ICP and the Cerebrovascular Bed by the Cholinergic Basal F orebrain"Acta Neurochirurgica. 71. 293-296 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori, M.Maeda: "Mechanism of_<201> Thallium-chloride uptake in tumor cells and its relationship to potassium channels"Neurological Research. 20. 19-22 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Mori, K.Cho, M.Maeda: "Thallium-201 Single Photon Emission Computed Tomography imaging of Meningioma Cells in Hyperostosis"Neurol Medico-chirurgica. 37. 594-599 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kentaro Mori, Minoru Maeda: "Use of [^3H] methylglucose and [^<14>C]iodoantipyrine to determine kinetic parameters of glucose transport in rat brain"Am. J.Physiol. R163-R171 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Maeda,M.Miyazaki: "Control of ICP and The Cerebrovascular Bed By the Basalocortical Neurovascular Pathway via The intracortical NO neurons"ICP 2000-Intracranial Pressure and Brain Monitoring. 223 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] A.Aoki,K.Mori,M.Maeda: "Appropriate Cerebral Perfusion Pressure During The Rewarming Period From Therapeutic Hypothermia"ICP 2000-Intracranial Pressure and Brain Monitoring. 117 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Mori,M.Maeda: "Misery perlusion caused by cerebral hypothermia improved by vasopressor administration"Neurological Research. 21. 585-592 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Mori,M.Maeda: "Effects of Mild and Moderate Hypothermia on Cerebral Metabolism and Glutamate in an Experimental Head injury"Acta Neurochirurgica. 71. 222-224 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Maeda: "Control of ICP and the Cerebrovascular Bed by the Cholinergic Basal Forebrain"Acta Neurochirurgica. 71. 293-296 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] K. Mori, M. Maeda: "Misery perfusion caused by cerebral hypothermia improved by vasopressor administration"Neurological Research. 21. 585-592 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Mori, M. Maeda: "Effects of Mild and Moderate Hypothermia on Cerebral Metabolism and Glutamate in an Experimental Head Injury"Acta Neurochirurgica. 71. 222-224 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] M. Maeda: "Control of ICP and the Cerebrovascular Bed by the Cholinergic Basal Forebrain"Acta Neurochirurgica. 71. 293-296 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Maeda: "Control of ICP and Cerebrovascular Bed by the Cholinergic Basal Forebrain" A‘cta Neurochirurgica. 71. 293-296 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Mori, M.Maeda: "Effects of Mild(33℃)and Moderate(29℃)hypothermia on cerebral blood flow and metabolism, lactate, and extracellular glutamate in experimental head injury" Neurological Research. 20. 719-726 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Mori, T.Yamaguchi, M.Maeda: "Mechanism of ^<201> Thallium-chloride uptake in tumor cells and its relationship to pottasium channels" Neurological Research. 20. 09-22 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Maeda: "Control of ICP and Cerebrovascular Bed by the Cholinergic Basal Forebrain" Acta Neurochirurgica (Suppl). 71. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Mori, M.Maeda: "Effects of Mild and Moderate Hypothermla on Cerebral Metabolism and Glutamate in an Experimental Head Injury" Acta Neurochirurgica (Suppl). 71. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Mori, M.Maeda: "Use of [^3H] methylglucose and [^<14>C] iodoampyrine to determine kinotic parameters of glucose transport in rat brain" American Journal of Physiology. 272. R163-R171 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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