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Basic research on spinal cord perfusion on acute spinal cord injury

Research Project

Project/Area Number 09671463
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionASAHIKAWA MEDICAL COLLEGE

Principal Investigator

SATO Masaki (1998)  Asahikawa Medical College, Orthopedics, lecturer, 医学部, 助手 (40281886)

岩原 敏人 (1997)  旭川医科大学, 医学部, 講師 (80133817)

Co-Investigator(Kenkyū-buntansha) ATSUTA Yuji  Asahikawa Medical College, Orthopedics, associate professor, 医学部, 講師 (90167924)
佐藤 雅規  旭川医科大学, 医学部, 助手 (40281886)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsspinal cord injury / spinal cord evoked potential / artificial cerebrospinal fluid / secondary degeneration / oxygenation / hyaluronic acid
Research Abstract

The purpose of this study is to evaluate the spinal cord function using spinal cord evoked potential (SCEP) and to analyze the effect of perfusion with artificial cerebrospinal fluid (aCSF) after the spinal cord injury.
Ten adult Wister rats were anesthetized and immobilized with halothane and suxamethonium chloride. The animal had a laminectomy at mid thoracic level and was fixed in a stereotaxic frame. Catheter electrodes were inserted through the laminectomy for SCEP recording. Spinal cord was injured by low velocity compression with microactuator until SCEP amplitude became just below 10% of the initial amplitude. In 5 animals, durotomy and spinal cord perfusion with normothermic oxygenated aCSF was performed for 4 hours. The other 5 animals were remained as non-treated controls.
4 hours after the injury, perfused animals showed the recovery of SCEP amplitude to 43.6% in average. In contrast, almost no potential was identified at this time in the control animals. The difference of the two groups was statistically significant, and this suggests that the local perfusion after acute spinal cord injury is a useful treatment for the functional recovery probably due to the suppression of secondary neuronal damage in early stage. Further study with longer observation and larger animals will be required.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 佐藤雅規、他: "頚髄症に対するPGE1と電気生理学的指標を用いた術後予後予測の試み" 東日本整災会誌. 10. 17-21 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小林徹也、他: "急性脊髄損傷に対するヒアルロン酸を用いた脊髄潅流の効果" 日本パラプレジア医学会雑誌. 11. 76-77 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 島崎俊司、他: "ヒアルロン酸ナトリウムが知覚神経週末に及ぼす機能的影響" 臨床リウマチ. 10. 91-95 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 佐藤雅規、他: "実験的脊髄損傷においてPGE1-αCDが運動誘発電位に及ぼす効果" 現代医療. 30. 153-158 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato M,et al: "Prediction of post-operative state of cervical myelopathy using prostaglandin E1 and electrophysiological parameters." East-Japan Orthopaedics and Traumatology. 10. 17-21 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kobayashi T,et al.: "The effect of perfusion with hyaluronic acid on spinal cord injury." Japan.J.of Paraplegia. 11. 76-77 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimazaki S.et all.: "The action of hyaluronic acid on sensory nerve endings." Clinical Rheumatology. 10. 91-95 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato M,et al.: "The effect of PGE-alpha CD on experimental spinal cord injury" Gendai Iryo. 30. 153-158 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 佐藤雅規、他: "頚髄症に対するPGE1と電気生理学的指標を用いた術後予後予測の試み" 東日本整災会誌. 10. 17-21 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小林徹也、他: "急性脊髄損傷に対するヒアルロン酸を用いた脊髄潅流の効果" 日本パラプレジア医学会雑誌. 11. 76-77 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 島崎俊司、他: "ヒアルロン酸ナトリウムが知覚神経週末に及ぼす機能的影響" 臨床リウマチ. 10. 91-95 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 佐藤雅規、他: "実験的脊髄損傷においてPGE1-αCDが運動誘発電位に及ぼす効果" 現代医療. 30. 153-158 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小林徹也、他: "急性脊髄損傷モデルにおける脊髄灌流の効果" 日本整形外科学会雑誌. 71. 1650 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 佐藤雅規、他: "ラット急性脊髄損傷モデルの運動誘発電位に対するPGE1-CDの効果" 日本パラプレジア医学会雑誌. 10. 60-61 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林徹也、他: "急性脊髄損傷モデルにおける脊髄灌流療法の有効性についての機能的評価" 脊髄電気診断学. 19. 1-4 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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