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Development of Bone Filler for Large Defect of Long Bone

Research Project

Project/Area Number 09671475
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

MATSUBARA Masaaki  Dept. of Orthop. Surg., TOKYO MEDICAL AND DENTAL UNIVERSITY, Assist. Professor, 医学部, 助手 (20251506)

Co-Investigator(Kenkyū-buntansha) MUNETA Takeshi  Dept. of Orfhop. Surg., TOKYO MEDICAL AND DENTAL UNIVERSITY,Professor, 医学部, 講師 (50190864)
長谷川 清一郎  東京医科歯科大学, 医学部, 助手 (00237968)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
KeywordsCM-Chitin / CM-Chitin-HA / BONE DEFECT / BONE FILLER / 充填材 / b-FGF / 骨欠損充填材 / 骨形成 / サイトカイレ
Research Abstract

As a filler for the bone defect, in making the chitin chitosan to be a raw material, carboxymethyl chitin-hydroxyapatite complex with the network structure was produced. In addition, bFGF impregnation CM chitin HA was also produced considering using CM chitin HA as Drug delivery system.
These new material were examined on the aptitude as a bone filler.
Results)
In present examination, the degree of the cross-link of the complex by a heat seemed to be insufficient. The material was comparatively absorbed in vivo since early stage, when it was implanted in tibia of the rabbit. It is considered that therefore, this complex does not inhibit the osteogenesis. In the meantime, the complex was rapidly absorbed in the experiment which transplanted the CM chitin in the radius bone defect model of the rabbit. And, non-infectious inflammation of the round cell invasion occurred, since the runoff of the bFGF has been early generated. As these results the osteogenesis was slow, when the complex was transplanted in the bone.
Since the solubility is high, the chitin chitosan has made that it is used for the organism with being difficult until now. Then, we developed a filler of the poor solubility using the heat cross-link technology.
When the bone defect is comparatively small, absorption rate of the complex was moderate, and the osteogenesis was observed from the peripheral part. However, the sufficient osteogenesis was not observed for large bone defect of the long bone, since the bone resorption is early.
Therefore, it is necessary to improve the control method of absorption rate in vivo in future.
It is expected that this complex becomes a safe and effective organization filler for the organism, if the control method of absorption rate is improved.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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