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RESEARCH FOR HA/ POLY-L-LACTIDE COMPOSITE AS BIORESORBABLE HIGH-STRENGTH OSTEOSYNTHETIC IMPLANTS

Research Project

Project/Area Number 09671487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MATSUSE Yoshitaka  KYOTO UNIVERSITY Department of Orthopaedic Surgery LECTURER, 医学研究科, 講師 (30209548)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Takashi  KYOTO UNIVERSITY Department of Orthopaedic Surgery PROFESSOR, 医学研究科, 教授 (10201675)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsRESORBABLE / HYDROXY APATITE / POLY-L-LACTIDE / COMPOSITE / FRACTURE REPAIR / BIOACTIVE / HIGH STRENGTH / bloactive / ceramic / hydroxyapatite / fixation / high strengtn
Research Abstract

The biodegradation behavior of the ultra-high-strength hydroxyapatite/poly(1-lactide) (HA/PLLA) composite rods for fracture repair was investigated both in subcutis and medullary cavity in rabbits. The bending strength of the composites implanted in the subcutis was maintained at more than 200 MPa at 25 weeks and at 150 MPa at 52 weeks. The molecular weight dropped to 45% of the initial values at S weeks and to approximately 10% at 52 weeks. SEM demonstrated that HA particles disappeared increasingly from the rod surfaces over time and that the spaces left by these HA particles formed many pores in the composite surfaces at 52 weeks. Histologically, a fibrous tissue layer was formed around the composite rod from 4 weeks in the subcutis and in the diaphyseal area of the medullary canal. In the medullary cavity, the affinity indices of all composite rods were significantly higher than those of unfilled PLLA rods during follow-up, (p < 0.01 ; two-way ANOVA). The maximum affinity index (4 1%) was attained at 4 weeks in c-HA40 rods. The only significant difference in affinity indices among the composites was that calcined HA40 had a higher affinity index than unsintered HA40 (p < 0.05 at 4 weeks). During the experimental period, there were no inflammatory cells such as mono- or multi-nuclear phagocytes. Although further long-term studies for degradation are needed, the composites have promising mechanical strength and no adverse tissue reaction for use as fracture-fixation devices during the experimental periods.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Y, Matsusue: "Tissue reaction of bioabsorbable ultra high strength poly(l-lactide)rod : A long term study in rabbits" Clin, Orthop. 317. 246-253 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y, Matsusue: "Bioabsorbable Pin Fixation of Osteochondral Fragment of the knee" Clin, Orthop. 322. 166-173 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y,Matsusue: "A long - term clinical study on drawn poly -L-lactide implants in orthopaedic surgery" J. Long-term Eff. Med. Impl.7. 119-137 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 古川, 泰三: "高強度アパタイト/ポリ-L-乳酸複合体:組織学的研究" 日整会誌. 71. S1747 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 古川, 泰三: "高強度水酸アパタイト/ポリ-L-乳酸複合体-生体内吸収過程の評価" 日整会誌. 72(8). S1594 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 泰永, 募: "高強度ハイドロキシアパタイト/ポリ-L-乳酸複合体と皮質肯表面との結合状態" 日整会誌. 72(8). S1614 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshitaka Matsusue, Takashi Nakamura, Hirokazu Iida, et al: "A long-term clinical study on drawn poly-L-lactide implants in orthopaedic surgery." J.Long-tem Eff.Med.Impl.7 (2). 119-137 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshitaka Matsuse: "application of bioresorbable implants." Pharma Medica. 16. 99-106 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Yasunaga, Y.Matsusue, T.Furukawa, et al: "Bonding behavior of ultra-high-strength HA/poly-L-lactide compsoites to the surface of the bone cortex." Jpn.J.Orthop.72 (8). S1614 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Furukawa, Y.Matsusue, T.Yasunaga, et al: "In vivo evaluation of biodegradation of ultra-high-strength HA/poly-L-lactide compsoites." Jpn.J.Orthop.72 (8). S1594 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shikinami Y,Okuno M.: "Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles/poly-L-lactide (PLLA) : Part I.Basic characteristics." Biomaterials. 20. 859-877 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Furukawa, Y.Matsusue, T,Yasunaga, et al: "Ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures : In vivo study." Ceramics in Medicine (New York) November. 5-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Matsusue: "Tissue reaction of bioabsorbable ultra high strength poly(1-lactide)rod : A long term study in rabbits." Clin.Orthop.317. 246-253 (1995)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Matsusue: "Bioabsorbable Pin Fixation of Osteochondral Fragment of The Knee." Clin.Orthop.322. 166-173 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Matsusue: "A long-term clinical study on drawn poly-L-lactide implants in orthopaedic surgery" J.Long-term Eff.Med.Impl.7. 119-137 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 古川 泰三: "高強度水酸アパタイト/ポリ-L-乳酸複合体 : 組織学的研究" 日整会誌. 71. S1747- (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 古川 泰三: "高強度アパタイト/ポリ-L-乳酸複合体-生体内吸収過程の評価" 日整会誌. 72 (8). S1594- (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 泰永 募: "高強度ハイドロキシアパタイト/ポリ-L-乳酸複合体と皮質骨表面と結合状態" 日整会誌. 72 (8). S1614- (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松末 吉隆: "生体内分解吸収性材料(Plla成形体)" 整形外科適用材料臨床応用マニュアル,Orthopaedics, 140 (1995)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Yamamuro: "A clinical study on bioabsorbable osteosynthetic implants made of ultra-high-strength poly-l-lactide" International Orthopaedics(SlCOT). 18(6). 332-340 (1994)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Hanafusa: "Biodegradable plate fixation of rabbit femoral osteotomies:A comparative study using dual energy X-ray absorptiometry" Clinical Orthopaedics. 315. 262-271 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Matsusue: "Tissue reaction of bioabsorbable Ultra high strength poly(l-lactide)rod:A long term study in rabbits" Clinical Orthopaedics. 317. 246-253 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Matsusue: "Bioabsorbable Pin Fixation of Osteochondral Fragment of The Knee" Clinical Orthopaedics. 322. 166-173 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Matsusue: "A long-term clinical study on drawn poly-L-lactide implants in orthopedic surgery" J.Long-term Eff.Med.Impl.7. 119-137 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 古川 泰三: "高強度アパタイト/ポリ-L-乳酸複合体:組織学的研究" 日本整形外科学会誌. 71. S1747 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 松末 吉隆: "ポリ-l-乳酸成形体:整形外科医用材料マニュアル" 金原出版, 175 (1992)

    • Related Report
      1997 Annual Research Report
  • [Publications] 松末 吉隆: "生体内分解吸収性材料(PLLA成形体)の開発と臨床応用;整形外科医用材料臨床応用マニュアル8(10)" Orthopaedics, 140 (1995)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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