| Project/Area Number |
09671496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | TOTTORI UNIVERSITY |
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Principal Investigator |
HAGINO Hiroshi FACULTY OF MEDICINE, TOTTORI UNIVERSITY, ASSISTANT PROF., 医学部, 講師 (80208412)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOMURA Tokio FACULTY OF MEDICINE, TOTTORI UNIVERSITY, ASSOCIATE PROF., 医学部, 助教授 (00216136)
OKANO Toru FACULTY OF MEDICINE, TOTTORI UNIVERSITY, INSTRUCTOR, 医学部, 助手 (60252871)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1999: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | BONE MINERAL MEASUREMENT / VDR POLYMORPHISM / ER POLYMORPHISM / BONE MARKER / ビタミンD受容体遺伝子 / 遺伝子多型 |
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| Research Abstract |
To assess allelic influence of the VDR gene on BMD, we determined changes in 1/6-radial-BMD by several repeat measurements in the same subjects for about ten years and analyzed VDR polymorphism of BsmI restriction enzyme in 263 normal healthy Japanese (male 130, female 133). Among these subjects, the distribution of bb, Bb and BB genotypes was 64.2%, 34% and 1.9%, respectively. There was no difference between the b group (women with bb genotype) and B group (women with BB or Bb genotype) in age, body weight, height, body mass index (BMI), years since menopause, serum osteocalcin and serum alkaline phosphatase values. In the POST group, BMD of the B group at menopause was lower than that of the b group (p <0.05). About ten years after menopause, BMD did not differ significantly between these groups because the decrease in BMD in the b group was larger than that in the B group. Our findings suggest that the differences in BMD by VDR genotype were larger among pre- and pri-menopausal women and seemed to decrease with years after menopause. It is suggested that there are other factors influencing BMD and postmenopausal bone loss in elderly women.
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