| Project/Area Number |
09671533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
TAKAHASHI Satoshi Hirosaki University Hospital, Department of Intensive Care Medicine, Assistant Professor, 医学部・附属病院, 助手 (10236276)
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| Co-Investigator(Kenkyū-buntansha) |
KOTANI Naoki Hirosaki University Hospital, Department of Anesthesiology, Instructor, 医学部・附属病院, 講師 (30205405)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | Anesthesia / operation / sleep / ketamine / isoflurane / Cytokine / TNF / interleukin / 睡眠 / イソフルレン / インターロイキン-1 / 腫瘍壊死因子 / 手術侵襲 / インターロイキン1 / 脳波 / 筋電 |
|---|
| Research Abstract |
Sleep is inhibited after operation. However, the mechanism of postoperative sleep disturbance is not well known. We hypothesized that anesthetics or somnogenic cytokine is involved in the postoperative sleep disturbances. Therefore, we studied the effects of an intravenous anesthetic agent, ketamine and a volatile anesthetic drug, isoflurane on sleep in rabbits. Ketamine increased non-rapid-eye-movement sleep (NREMS) and electroencephalogram slow wave activity. In contrast, isoflurane reduced NREMS. These results suggest that volatile anesthetics but not ketamine may enhance the postoperative sleep disturbance. Furthermore, we studied that the somnogenic relationships between tumor necrosis factor and interleukin-1. In this study, we found that tumor necrosis factor and interleukin-1 are closed linked to regulate physiological sleep and pathological sleep. Since operation stimulates cytokine network, these somnogenic cytokines should be related to postoperative sleep disturbances.
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