| Project/Area Number |
09671540
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
SATO Jiro Chiba University, School of Medicine, Lecturer, 医学部, 講師 (90187203)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AONO Mitsuo Chiba University, School of Medicine, Assistant, 医学部, 助手 (40292693)
NISHINO Takashi Chiba University, School of Medicine, Professor, 医学部, 教授 (80009703)
杉森 邦夫 千葉大学, 医学部, 助手 (20241961)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
|
|---|
| Keywords | nitrous oxide / carbon dioxide / dynamic cerebrovascular respons / mathematical model / transcranial Doppler ultrasonography / propofol / 数理モデル / 脳血流 / 炭酸ガス負荷 |
|---|
| Research Abstract |
We studied the effect of N_2O on the dynamic cerebrovascular response to changes in end-tidal CO_2 tension (PETCO_2) in healthy humans. By use of a transcranial Doppler ultrasonography, blood flow velocity in the middle cerebral artery (_VMCA) was measured during a step increase followed by a step decrease in PETCO_2 between normo- and hypercapnia while subjects inspired gas mixtures containing 70% O_2 + 30% N_2 (control) and 70% 0_2+30% N_2O (N_2O) separately. In control gas breathing, both step increase and decrease in PETCO_2 produced rapid exponential changes in ^VMCA.An increase in _VMCA produced by the step increase in PETCO_2 was smaller (P < 0.001) and slower (P < 0.001) than a decrease in _VMCA induced by the step decrease in PETCO_2. These general features of the dynamic cerebrovascular response were not affected by N_2O gas breathing although N_2O increased baseline ^VMCA by 15% (P (0.001) compared with control gas breathing. We conclude that N_2O in itself does not affect the dynamic cerebrovascular response to arterial CO_2 changes although N_2O produces static mild cerebral vasodilation. We also examine the effect of propofol on the cerebrovascular dynamic response to PETCO2. When added to N_2O, propofol produced the baseline cerebral vaso constriction. Propofol blunted the dynamic cerebrovascular response to changes in PETCO2.
|
