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EFFECTS OF NMDA-ATAGONISTS AND ALPHA2-ADRENERGIC AGONISTS ON SPINAL AND CEREBRAL MICROCIRCULATION -ASSESSED WITH CLOSED SPINAL AND CRANIAL WINDOW TECHNIQUE-.

Research Project

Project/Area Number 09671555
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGIFU UNIVERSITY

Principal Investigator

IIDA Hiroki  DEPARTMENT OF ANESTHESIOLOGY AND CRITICAL CARE MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (30159561)

Co-Investigator(Kenkyū-buntansha) DOHI Shuji  DEPARTMENT OF ANESTHESIOLOGY AND CRITICAL CARE MEDICINE, PROFESSOR, 医学部, 教授 (40155627)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1999: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsNMDA antagonist / Alpha2-adrenergic agonist / Cerebral vessel / Spinal vessel / Microcirculation / α_2作動薬 / 脳・脊髄循環 / 微小循環
Research Abstract

Pentobaribital anesthetized animals were prepared for measurement of cerebral and spinal pial vessel diameter in a cranial and a spinal window preparation. We investigated the experiments according to following protocols.
(1) To investigate the effect of systemic pretreatment with dexmedetomidine on cerebrovascular response to isoflurane and sevoflurane.; The vasodilation of cerebral pial vessels induced by isoflurane and sevoflurane could be attenuated by the systemic administration of dexmedetomidine, and this interaction between dexmedetomidine and volatile anesthetics showed no evidence of dose dependency.
(2) To investigate the effect of ketamine on cerebrovascular response to isoflurane and sevoflurane.; Ketamine itself did not induce cerebrovascular dilation. The vasodilation of cerebral pial vessels induced by isoflurane and sevoflurane could be attenuated by the systemic administration of ketamine, and the response of pial vessels to PaCO2 also attenuated.
(3) To investigate the effects of alpha1- and alpha2-adrenergic agonists on spinal and cerebral pial vessels: Dexmedetomidine and clonidine constricted spinal vessels in a concentration-dependent manner, but such vasoconstrictions were smaller than those induced by phenylephrine and epinephrine. In cerebral vessels, greater constriction was induced by dexmedetomidine and clonidine than those induced by phenylephrine and epinephrine.
(4) To investigate the effects of spinal alpha2-adrenergic agonists on cerebrovascular reactivity to hypercapnia and hypoxia.: The presence of alpha2-adrenergic agonist administered intrathecally into the lumbar spinal region attenuated hypercapnic, but not hypoxic cerebral vasodilation, probably via a stimulation of central alpha2-adrenergic receptors of the central nervous system.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Mami Iida, et al.: "Mechanisms underlying cerebrovascular effects of cigarette smoking in rats in vivo"Stroke. 29. 1656-1665 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroki Iida, et al.: "Isoflurane and sevoflurane induce vasodilation of cerebral vessels via ATP-sensitive K^+ channel activation"Anesthesiology. 89. 954-960 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroto Ohata, et al.: "Intravenous dexmedetomidine inhibits cerecrovascular dilation induces by isoflurane and sevoflurane in dogs"Anesth Analg. 89. 370-377 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroto Ohata, et al.: "Hemodynamic responses induced by dopamine and dobutamine in anesthetized patients premedicated with clonidine"Anesth Analg. 89. 843-848 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroki Iida, et al.: "Direct effects of α_1- and α_2-adrenergic agonists on spinal and cerebral pial vessels in dogs"Anesthesiology. 91. 479-485 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroki Iida, et al.: "Attenuated additional hypocapnic constriction, but not hypercopnic dilation of spinal pial arterioles during spinal ropivacuine"Anesth Analg. 89. 1510-1513 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iida M, Iida H, Dohi S, Takenaka M, Fujiwara H: "Mechanisms underlying cerebrovascular effects of cigarette smoking in rats in vivo."Stroke. 29. 1656-1665 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iida H, Ohata H, Iida M, Watanabe Y, Dohi S: "Isoflurane and sevoflurane induce vasodilation of cerebral vessels viaATP-sensitive KィイD1+ィエD1 channel activation."Anesthesiology. 89. 954-960 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohata H, Iida H, Dohi S, Watanabe Y: "Intravenous dexmedetomidine inhibits cerebrocascular dilation induced by isoflurane and sevoflurane."Anesth Analg. 89. 370-377 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohata H, Iida H, Watanabe Y, Dohi S: "Hemodynamic responses induced by dopamine and dobutamine in anesthetized patients premedicated with clonidine."Anesth Analg. 89. 843-848 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iida H, Ohata H, Iida M, Watanabe Y, Dohi S: "Direct effects of α1- and α2-adrenergic agonists on spinal and cerebral pial vessels in dogs."Anesthesiology. 91. 479-485 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iida H, Ohata H, Iida M, Watanabe Y, Nagase K, Dohi S: "Attenuated additional hypocapnic constriction, but not hypercapnic dilation, of spinal pial arterioles during spinal ropivacaine."Anesth Analg. 89. 1510-1513 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroto Ohata,et al.: "Intravenous dexmedetomidine inhibits cerebrovascular dilation induced by isoflurane and sevoflurane in dogs"Anesth Analg. 89. 370-377 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroto Ohata,et al.: "Hemodynamic responses induced by dopamine and dobutamine in anesthetized patients premedicated with clonidine"Anesth Analg. 89. 843-848 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroki Iida,et al: "Direct effects of α1-and α2- adrenergic agoristson spinal and cerebral dial vessels in dogs"Anesthesiology. 91. 479-485 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroki Iida,et al.: "Attenuated additional hypocapnic constriction,but not hypercapric dilation,of spinal dial arteroles during spinal ropivacaine"Anesth Analg. 89. 1510-1513 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mami Iida,et al.: "Mechanisms underlying cerebrovascuar effects of cigreHe smoking in rats in vivo" Stroke. 29. 1656-1665 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroki Iida,et al.: "Isoflurane and sevoflurane induce vasodilation of cerebral vessels via ATP-sensitive K^+ channel activation" Anesthesiology. 89. 954-960 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ishiyama T.: "The Vascular Effects of Topicaland Intravenous Alpha-2 Adrenoceptor Agonist Clonid:ne on Canine Pial Microcirculation" Anesthesia & Analgesia. (in press). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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