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Effects of Nitric Oxide Synthase Inhibitor on Organ Blood Flow Distribution during Hemorrhagic Shock

Research Project

Project/Area Number 09671586
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTeikyo University

Principal Investigator

FUJIOKA Susumu  Teikyo University, Dept.of Anesthesiology, associate, 医学部, 助手 (00276768)

Co-Investigator(Kenkyū-buntansha) OKADA Kazuo  Teikyo University, Dept.of Anesthesiology, professor, 医学部, 教授 (30082093)
INADA Eiichi  Teikyo University, Dept.of Anesthesiology, professor, 医学部, 教授 (40193552)
FUNAYAMA Tadahisa  Teikyo University, Dept.of Anesthesiology, associate, 医学部, 助手 (70238658)
MIZUMOTO Kiyoshi  Teikyo University, Dept.of Anesthesiology, associate, 医学部, 助手 (20190663)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordshemorrhagic shock / nitric oxide / adrenomedullin / 一酸化窒素合成酵素阻害剤 / 臓器血流分布
Research Abstract

1, We investigated the effects of nitric oxide synthase (NOS) inhibitor on organ blood flow distribution in hemorrhagic shock. In anesthetized dogs, hypotension (mean arterial pressure=4OmmHg) was achieved by draining blood from their circulation into a reservoir and maintained for 90 mm by further removing or transfusing blood. Following the 90 mm shock period, 10mg/kg N-nitro-L-arginine methyl ester (L-NAME group : n=8) or saline (control group : n=8) was administered. Organ blood flow distribution was measured before hypotension and I 5mm after L-NAME or saline administration in both groups by the radioactive microsphere method. There was no signicant difference in organ blood flow distribution between the two groups. A physiological shift in blood flow distribution during hemorrhagic shock to the brain and heart (centralization) was observed in both groups. (Circulation Control 1 8 ; 541-547 : 1997)
2, We also investigated the change of plasma concentration of adrenomedullin, a novel vasodilating peptide, in hemorrhgic shock. In anesthetized dogs, hypotension (mean arterial pressure=4OmmHg) was achieved by draining blood from their circulation into a reservoir and maintained for 90 mm by further removing or transfusing blood. Plasma concentration of adrenomedullin was increased in hemorrhagic dogs (n=8) more significantly than in sham dogs (n=8). (Anesthesia & Analgesia 88 ; 326-328 : 1999)

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 藤岡 丞: "出血性ショックにおける一酸化窒素合成酵素阻害剤の投与が臓器血流分布に及ぼす影響" 循環制御. 18. 541-547 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Susumu Fujioka: "Plasma concentration of actenamedllinis increased in hemarrhagic shock in dogs" Anesthesia & Analgesia. 88. 326-328 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] "Effects of nitric oxide synthase inhibitor on organ flow distribution during hemorrhagic shock" Circulation Control. 18. 541-547 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] "Plasma concentration of adrenomedullin is increased in hemorrhagic shock in dogs" Anesthesia & Analgesia. 88. 326-328 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 藤岡 丞: "出血性ショックにおける一酸化窒素合成酵素阻害剤の投与が臓器血流分布に及ぼす影響" 循環制御. 18. 541-547 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Susumu Fujioka: "Plasma concentration of act enomedulin is increased in hemarrhagic shock in dogs" Anesthesia&Analgesia. 88. 326-328 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 藤岡 丞: "出血性ショックにおいてNO合成酵素阻害が臓器流血分布に及ぼす影響" 循環制御. 18. 541-547 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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