| Project/Area Number |
09671596
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | University of Occupational Environmental Health(UOEH) |
|---|
Principal Investigator |
SATA Takeyoshi University of UOEH, The faculty of medicine, assosiate professor, 医学部, 助教授 (60128030)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Takashi University of UOEH, The faculty of medicine, instructor, 医学部, 助手 (60299633)
MINAMI Koichiro University of UOEH, The faculty of medicine, instructor, 医学部, 助手 (70279347)
SEGAWA Kayoko University of UOEH, The faculty of medicine, instructor, 医学部, 助手 (70289578)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | mesangial cell / ketamine / propofol / [Protein Kinase A / Protein Kinase / 蛋白燐酸化酵素 / 〔^3H〕-thymidine / 尿中代謝産物 / メサンギウム細胞 / ケタミン / protein kinase A / protein kinase C |
|---|
| Research Abstract |
We studied the effects of intravenous anesthetics ketamine and propofol on rat mesangial cell (MC) proliferation. Ketamine inhibited [3H]tymidine incorporation into the mesangial cells in a concentration-dependent manner (10 mM*1 mM). But, Propofol had no effects on [3H]tymidine incorporation. Ketamine also attenuated the cell number at clinical concentrations and increased cAMP levels in MC.Protein Kinase A inhibitor recovered the inhibition of ketamine on MC proliferation. Ketamine kept the renal blood flow in Rat in vivo. These results suggested that ketamine have inhibitory effects on the MC proliferation via protein kinase pathway and ketamine may be useful to suppress the progression of chronic renal failure.
|
