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On the cause for the urinary incontinence derived from overactive detrusor muscles : Analysis by morphological changes in cell junctions

Research Project

Project/Area Number 09671605
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionChiba University

Principal Investigator

TOYAMA Yoshiro (1998-1999)  CHIBA UNIVERSITY SCHOOL OF MEDICINE, LECTURER, 医学部, 講師 (70009637)

山西 友典 (1997)  千葉大学, 医学部, 講師 (90220425)

Co-Investigator(Kenkyū-buntansha) YASUDA Kousaku  DOKKYO MEDICAL SCHOOL, KOSHIGAYA HOSPITAL, PROFESSOR, 越谷病院, 教授 (70009710)
YAMANISHI Tomonori  CHIBA UNIVERSITY SCHOOL OF MEDICINE, LECTURER, 医学部, 講師 (90220425)
外山 芳郎  千葉大学, 医学部, 講師 (70009637)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsLOWER URINARY TRACT / URINARY BLADDER / DETRUSOR MUSCLE / URINARY TRACT SYMPTOMS / AGING / ULTRASTRUCTURE / GAP JUNCTION / 排尿機能 / 尿流動態検査 / 排尿筋過活動 / 前立腺肥大症
Research Abstract

One of the causes for the urinary incontinence in aged man is considered to be overactivity of the detrusor muscles. The function of detrusor muscles of 32 aged patients with bladder neck constracture were analysed by a video-urodynamics method using a microtip-transducer. The effects of terazosin, an adrenalin receptor α, on the detrusor muscle were also examined. Biopsy samples from patients with baldder neck constracture were also examined by electron microscopy. Distribution pattern of slow muscle fibers and fast muscle fibers and the ratio of slow to fast muscle fibers were examined by a histochemical method.
The results showed that bladder neck constracture in most patients was organic, and the adrenalin receptor α was dominant to the adrenalin receptor β in the detrusor muscles in the patients with bladder neck constracture. Electron micrographs showed that the gap junctions in the detrusor muscles in the patients with lower urinary tract symptoms were hypotrophic, indicating that overactivity of the urinary bladder with lower urinary tract symptoms was derived from hypoplastic gap junctions between muscle cells in the detrusor. The fast and slow muscle fibers were mixed randomly in the detrusor muscles of the dog. A specific distribution pattern with aging was not found.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] T.Yamanishi et al.: "A randomized, double-blind study of electrical stimulation for urinary incontinence due to detrusor overactivity"Urology. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Toyama et al.: "Decapitated and decaudated spermatozoa in man, and pathogenesis based on the ultrastructure"Int. J. Androl.. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yamanishi et al.: "The effectiveness of terazosin, an alpha-blocker, on bladder neck obstruction as assessed by urodynamic hydraulic energy"BJU Int.. 85. 249-253 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Yasuda & T.Yamanishi: "Critical evaluation of electro-stimulation for management of female urinary incontinence"Curr. Opin. Obstet. Gynecol.. 11. 503-507 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yamanishi et al.: "Induction of urethral closure and inhibition of bladder contraction by continuous magnetic stimulation"Neurol. Urodynam.. 18. 505-510 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Toyama et al.: "Histological characterization of defective spermatogenesis in mice lacking the basigin gene"Anat. Histol. Embryol.. 28. 205-213 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yamanishi, K.Yasuda, R.Sakakibara, T.Hattori, S.Suda.: "A randomized, double-blind study of electrical stimulation for urimary incontinence due to detrusor overactivity."Urology. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Toyama, T.Imamoto, M.Yajima, K.Baba, S.Yuasa: "Decapitated and decaudated spermatozoa in man, and pathogenesis based on the ultrastructure"Int.J.Androl. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yamanishi, K.Yasuda, R.Sakakibara, T.Hattori, M.Tojo: "The effectiveness of terazosin, an alpha-blocker, on bladder neck obstruction as assessed by urodynamic hydraulic energy."BJU Int. 85. 249-253 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Yasuda and T.yanamishi: "Critical evaluation of electro-stimulation for management of female urinary incontinence"Curr. Opin. Obstet. Gynecol. 11. 503-507 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yamanishi, K.Yasuda, R.sakakibara, S.Suda, N.Ishikwa.: "Induction of uerthral closure and ingibition of bladder contraction by continuous magnetic stimulation"Neurol. Urodynam. 18. 505-510 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Toyama, M.Maekawa, K.kadomatsu, T.Miyauchi, T.Muramatsu, S.Yuasa: "Histological characterization of defective spermatogenesis in mice lacking the basigin gene"Anat Histol. Embryol.. 28. 205-213 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Yamanishi et al.: "A randomized, double-blind study of electrical stimulation for urinary incontinence due to detrusor overactivity"Urology. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Toyama et al.: "Decapitated and decaudated spermatozoa in man, and pathogenesis based on the ultrastructure"Int. J. Androlol.. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] T. Yamanishi et al.: "The effectiveness of terazosin, an alpha-blocker, on bladder neck obstruction as assessed by urodynamic hydraulic energy"BJU Int.. 85. 249-253 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Yasuda and T. Yamanishi: "Critical evaluation of electro-stimulation for management of female urinary incontinence"Curr. Opin. Obstet. Gynecol.. 11. 503-507 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T. Yamanishi et al.: "Induction of urethral closure and inhibition of bladder contraction by continuous magnetic stimulation"Neurol Urodynam. Neurol. Urodynam.. 18. 505-510 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Toyama et al.: "Histological characterization of defective spermatogenesis in mice lacking the basigin gene"Anat. Histol. Embryol.. 28. 205-213 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Toyama et al.: "Histological characterization of defective spermatogenesis in mice lacking the basin gene." Anat Histol Embryol. (印刷中).

    • Related Report
      1998 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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