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Investigation on optimal conditions of 5 α-reductase inhibitor in prevention of prostate carcinogenesis

Research Project

Project/Area Number 09671610
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionThe University of Tokyo

Principal Investigator

HOMMA Yukio  University of Tokyo, (Branch Hospital), Department of Urology, Associate professor, 医学部・附属病院・分院, 助教授 (40165626)

Co-Investigator(Kenkyū-buntansha) KONDO Yasushi  University of Tokyo, (Hospital), Department of Urology, Assistant, 医学部・附属病院, 助手 (70178432)
TAKAHASHI Satoru  University of Tokyo, (Branch Hospital), Department of Urology, Lecturer, 医学部・附属病院・分院, 講師 (50197141)
田中 良典  東京大学, 医学部・附属病院, 助手 (50236650)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Keywordsprostate carcinogenesis / 5α-reductase inhibitor / FK143 / carcinogenesis inhibition / 5α-reductase / 5α-reductase inhibitor / ラット前立腺
Research Abstract

We examined whether a 5 α-reductase inhibitor, FK143, does or does not suppress prostate carcinogenesis in spontaneously cancer-developing rat model, ACI/Seg rats. The rats were fed on diet containing FK143 at 20ppm or 200ppm from 80 weeks to 140 weeks of age, or at 20ppm from 6 weeks, 40 weeks and 60 weeks to 100 weeks of age. At the end of treatment, the rats were sacrificed for histological examinations and tissue androgen assay for the ventral prostate. Carcinogenesis was inhibited only in that incidence of macroscopic cancer was significantly less frequent in those fed 20ppm of FK143 from 80 weeks to 140 weeks. In any other groups the incidence of atypical hyperplasia, microscopic cancer or macroscopic cancer was comparable or even increased compared with the control. Androgen assay showed significant suppression of dihydrotestosterone concentration in any treated groups. However testosterone concentration was unaffected only in the group in which carcinogenesis was suppressed ; it was reciprocally increased in other groups in which carcinogenesis was NOT suppressed. Taken together, FK143 inhibits 5 α-reductase activity in the rat prostate and may suppress carcinogenesis provided it does not accumulate the substrate, testosterone, in the prostate.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Homma,Y et al: "Inhibition of rat prostate carcinogenesis by a 5α-reductase inhibitor,FK143"J.National Cancer Institute. 89. 803-807 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Homma, Y., Kaneko, M., Kondo, Y., Kawabe, K., Kakizoe, T.: "Inhibition of rat prostate carcinogenesis by a 5α-reductase inhibitor, FK143."J.Natl.Cancer Inst.. 89. 803-807 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary

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Published: 1998-04-01   Modified: 2016-04-21  

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