| Project/Area Number |
09671625
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
KAMOTO Toshiyuki Kyoto University, Graduate school of medicine, assistant prof., 医学研究科, 助手 (00281098)
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| Co-Investigator(Kenkyū-buntansha) |
TERAI Akito Kyoto University, Graduate school of medicine, assistant lecturer, 医学研究科, 講師 (50243019)
SHIGENO Choei Kyoto University, Graduate school of medicine, assistant prof., 医学研究科, 助手 (30170864)
KAWAKITA Mutsushi Kansai Medical University, associate prof., 医学部, 助教授 (70234036)
MIZUTANI Youichi Kyoto University, Graduate school of medicine, assistant prof., 医学研究科, 助手 (10243031)
YUSAKU Okada Shiga Medical University, Professor, 医学部, 教授 (20127062)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | bone mineral density / acidosis / urinary diversion / animal model |
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| Research Abstract |
To clarify the mechanism of bone demineralization following urinary diversions using intestinal segments and by metabolic acidosis, the bone mineral densities of the lumber spine were measured with DEXA, and urinary pyridinium and serum osteocalcin, calcium, and phosphate were measured at 0, 2, 4, 8-week. Male rats were divided into 5 groups ; the control group without any treatment, the acidosis group treated with 1.5% NII4Cl water, the augmentation group the bladder of which was augmented with the terminal ileum, the sham group a similar length of the terminal ileum of which was removed, and the re-anastomosis group the ileum of which was incised and then re-anastomosed. The bone mineral densities of the augmentation and sham groups decreased at 2-week, whereas those of the acidosis group had no change in two months. No differences were found in urinary pyridinium among all groups. Serum calcium increased in the control and re-anastomosis groups, had no change in the acidosis group, and decreased in the augmentation and sham groups. The bone demineralization of the augmentation group had a similar pattern to the sham group rather than the acidosis group. These data indicated that the removal of the terminal ileum might induce bone demineralization associated with serum calcium decrease.
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