| Project/Area Number |
09671638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | YOKOHAMA CITY UNIVERSITY |
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Principal Investigator |
NOGUCHI Sumio YOKOHAMA CITY UNIVERSITY, UROLOGY, ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授 (40137047)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Mitsunobu YOKOHAMA CITY UNIVERSITY, UROLOGY, ASSOCIATE PROFESSOR, 医学部・附属市民総合医療センター, 助教授 (90244459)
KUBOTA Yoshinobu YOKOHAMA CITY UNIVERSITY, UROLOGY, ASSOCIATE PROFESSOR, 医学部, 助教授 (10106312)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | PROSTATE CANCER / STROMAL CELL / INTERLEUKIN-6 / CMA / 組織型 |
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| Research Abstract |
We focused on stromal component which was abundantly included for the poorly differentiated prostatic cancer (column and cord) and the direct effect of antiandrogen(CMA) to the prostatic stromal cells. Stromal cell proliferation in serum free culture was dose-dependently inhibited by CMA and IL-6 recovered these inhibitory effects. IL-6 concentration in conditioned medium of stromal cells was decreased by CMA(10-9 M〜10-6M). IL-6 mRNA were present in stromal cells from prostatic tissues but CMA did not effect the expression of mRNA level.
From these results, it was indicated that IL-6 release to the CM decreased by lowering the permeability of the cell membrane of stromal cells by CMA.
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