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Investigation of Biological Behavior and Treatment Modality for Ovarian Clear Cell Adenocarcinoma

Research Project

Project/Area Number 09671667
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

FUJIMURA Masaki  Toyama Medical and Pharmaceutical University, Hospital, Instructor, 附属病院, 講師 (80242501)

Co-Investigator(Kenkyū-buntansha) SAITO Shigeru  Toyama Medical and Pharmaceutical University, Faculty of Medicine, Prof., 医学部, 教授 (30175351)
TSUDA Hiroshi  Toyama Medical and Pharmaceutical University, Hospital, Assist. Prof., 附属病院, 助手 (80293314)
HIDAKA Takao  Toyama Medical and Pharmaceutical University, Hospital, Assist. Prof., 附属病院, 助手 (70283083)
YAMAKAWA Yoshihiro  Toyama Medical and Pharmaceutical University, Faculty of Medicine, Instructor, 医学部, 講師 (90191212)
泉 陸一  富山医科薬科大学, 医学部, 教授 (30010177)
伏木 弘  富山医科薬科大学, 医学部, 講師 (70173375)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
KeywordsOvarianclearcell adenocarcmoma / Chemo-resistant ovarian cancer / Growth Faetor / EGF-R / HER2 / neu / Monoclonal antibody / ZD1839 / HERCEPTIN / 明細胞腺癌 / 卵巣癌 / チロシンキナーゼ / サイトカイン / Clear cell adenocarcinoma / Ovarian cancer / Tyrosin Kinase / Cytokine / 薬剤耐性 / ステロイドホルモンレセプター / HRT
Research Abstract

The basic anti-caner drug for treating ovarian clear cell adenocarcinoma (CCA) was revealed to be CPT-ll. Hyperthermia and Glycerol addition which were known as enhencer of anti-cancer drug, have insufficient effect on its clinically available condition. Estrogen receptor-α (ER α), and ER β were not expressed in clinically resected Ovarian CCA specimens and cultured CCAcell lines. EOF and TGF α stimulation through EGF-R, which was thought to be located at the lower stream of ERα, stimulated the growth and invasion of CCA cell lines by autocline system. Stimulation through HER2 was also involved in the growth of ovarian CCA cell lines. Then Iressa, a specific inhibitor of EGF-R phosphorylation, inhibited the growth and invasion of CCA cell lines dose dependently. Iressa also inhibit the growth of xenografted CCA(RMG-l) on the back of SCID mice. The mice in which Iressa was administered survived more longer than the mice in control group. Herceptin which is known as humanized anti-HER2 monoclonal antibody, also inhibited the growth of CCA cell line in vitro and in vivo. Also Herceptin administered mice survived more longer than the mice in control group.
From these findings, Iressa and Herceptin were revealed to be potent inhibitors of CCA cell lines and could be a good candidate as one of clinically comprehensive treatment modality for CCA.

Report

(5 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 藤村正樹, 片岡 健, 日高隆雄, 斎藤 滋: "卵巣明細胞腺癌における抗癌剤感受性試験"Oncology & Chemotherapy. 16. 241-244 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimura M, Hidaka T, Kataoka K et al.: "Absence of estrogen receptor-α expression in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma"Am J Surg Pathol. 25. 667-672 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimura M, Hidaka T, Saito S: "Selective inhibition of the epidermal growth factor receptor by ZD1839 ('IRESSA') decreses the growth and invasion of ovarian clear cell adenocarcinoma cells"Clin Cancer Res. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimura M., Kataoka K, Hidaka T. and Saito S.: "Sensitivity test of anti-cancer drugs for ovarian clear cell adenocarcinoma."Oncology and Chemotherapy. 16. 241-244 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimura M., Hidaka T., Kataoka K, Yamakawa Y., Akada S., Teranishi A. and Saito S.: "Absence of estrogen receptor-α expression in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma."Am. J. Surg. Pathol. 25. 667-672 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimura M., Hidaka T., Saito S.: "Selective inhibition of the epidermal growth factor receptor by ZD1839 ('IRESSA') decreses the growth and invasion of ovarian clear cell adenocarcinoma cells"Clin. Cancer Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimura M.,Yamakawa Y.,Kataoka K. et al.: "Preservation of the vulva in stage III squamous cell carcinoma with intra-arterial chemotherapy."Int.J.Clin.Oncol.. 4. 307-310 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 藤村正樹,片岡健,日高隆雄,斎藤滋: "卵巣明細胞腺癌における抗癌剤感受性試験"Oncology and Chemotherapy. 16. 241-244 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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