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Chemotherapy effects for ovarian cancer : Special reference of immuhistochemical and morphological study based on the fuzzy logic

Research Project

Project/Area Number 09671692
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

AMADA Satoshi (1998-1999)  Faculty of Medicine, Kyushu University, Assistant Professor, 医学部, 助手 (10294919)

重松 敏之 (1997)  九州大学, 医学部, 助手 (30253438)

Co-Investigator(Kenkyū-buntansha) SAKAI Kunihiro  Faculty of Medicine, Kyushu University, Assistant Professor, 医学部, 助手 (70264033)
KAKU Tsunehisa  School of Health Science, Kyushu University, Associate Professor, 医療技術短期大学部, 助教授 (60185717)
嘉村 敏治  九州大学, 医学部, 助教授 (30152870)
斎藤 俊章  国立病院九州がんセンター, 医長 (80162212)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsOvarian cancer / Chemotherapy / Drug resistance / 腹水細胞診 / ファジィ理論 / インテグリン / MIB-1 / CD44-v6 / 体腔細胞 / 治療効果判定モデル
Research Abstract

Nuclear expression of Y box-binding protein (YB-1), a member of the DNA binding protein family, has been reported to be much more highly concentrated in cisplatin-resistant cell lines than in their parental counterparts, suggesting an ability to limit cisplatin sensitivity. Moreover, YB-1 plays a key role in P-glycoprotein expression. Because ovarian carcinoma traditionally has been treated with cisplatin-based chemotherapy, the sensitivity of the tumors to chemotherapy could reflect a particular prognosis inpatients with ovarian carcinoma. The aim of our study was to determine whether YB-1 expression correlated with prognosis in ovarian serous adenocarcinoma patients. The expression of YB-1 in the nucleus was examined immunohistochemically in 42 paraffin embedded primary Stage II serous ovarian carcinoma tumors extirpated by primary surgery at Kyushu University Hospital between 1985-1995. Of the 40 primary ovarian tumors examined, 12 (30%) were positive for YB-1 expression in the nucl … More eus. There was no significant difference in intraperitoneal stage, histologic grade, or residual tumor size after primary surgery between patients with tumors with positive and those with negative nuclear expression of TB-1 protein. The disease free survival curve for patients whose tumors were positive for nuclear expression of YB-1 protein was significantly worse than that for patients whose tumors were negative. The expression of YB-1 protein in the nucleus may be considered a useful prognosis marker and also may reflect the sensitivity of ovarian serous adenocarcinoma to chemotherapy. (Cancer 85 : 2450-4, 1999) Moreover, we reported the correlation of YB-1 positivity between serous carcinoma and clear cell one of the ovary. Seventy-two % of the cleat cell carcinomas were positive for YB-1 compared with 30% of the serous carcinomas. These findings suggested that YB-1 expression was one of the worse prognostic factors in the clear carcinoma which indicated cisplatin resistance. (50ィイD1thィエD1 Annual congress of Japan Society of Obstetrics and Gynecology, April 21, 1998) We further examined the recurrent lesions of the ovarian carcinomas. Fourteen of 16 cases which showed YB-1 expression at the primary lesions were positive at the recurrent lesions. Ten recurrent lesions revealed YB-1 positivity in 19 cases with YB-1 negative primary lesions. (51ィイD1stィエD1 Annual congress of Japanese Society of Obstetrics and Gynecology, April 13, 1999). According to the above our results , YB-1 expression is a useful marker for judgement of the chemotherapy effects in the ovarian carcinoma. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Kamura T, Yahata H et al: "Is nuclear expression of Y Box-Binding Protein-1 a new prognostic factor in ovarian seros adenocarcinoma ?"Cancer. 85. 2450-2454 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakai K, Kaku T, et al: "Comparison of p53, Ki-67 and CD44v6 expression between primary and matched metastatic lesions in ovarian cancer"Gynecologic Oncology. 72. 360-366 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hirakawa T, Kamura T, et al.: "Prognostic significance of epithelial-stromal vascular cuffing and microvessel density in squqmous cell carcinoma of the uterine cervix"Gynecologic Oncology. 74. 369-374 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamura T, Yahata H, et al: "Predicting pelvic lymph node metastasis in endometrial carcinoma"Gynecologic Oncology. 72. 387-391 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue Y, Kamura T, et al.: "Efficacy of selective venous sampling to localiza a small ovarian andorogen-producing tumor"Journal of Obstetrics and Gynecologgy Research. 25. 231-235 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kaku T, Sonoda K, et al.: "The prognostic significance of tumor-associated antigen 22-1-1 expression in adenocarcinoma of the uterine cervix"Clinical Cancer Research.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamura T, Yahata H, Amada S, Ogawa S, Sonoda T, Kobayashi H, Mitsumoto M, Kohno K, Kuwano M, Nakano H.: "Is nuclear expression of YB-1 Binding Protein-1 a new prognostic Factor in ovarian serous adenocarcinoma?"Cancer. 85. 2450-2454 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakai K, Kaku T, Kamura T, Kinukawa N, Amada S, Shigematsu T, Hirakawa T, Kobayashi H, Ariyoshi K, Nakano H.: "Comparison of p53, Ki-67, and CD44v6 expression between primary and matched metastatic lesions in ovarian cancer"Gynecol Oncol. 72. 360-366 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hirakawa T, Kamura T, Kaku T, Amada S, Ariyoshi K, Kinukawa N, Nakano H.: "Prognostic significance of epithelial-stromal vascular cuffing and microvessel density in squamous cell carcinoma of the uterine cervix"Gynecol Oncol. 74. 369-374 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamura T, Yahata H, Shigematsu T, Ogawa S, Amada S, Kaku T, Nakano H.: "Predicting pelvic lymph node metastasis in endometrial carcinoma"Gynecol Oncol. 72. 387-391 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue Y, Kamura T, Okuma A, Shigematsu T, Amada S, Ogawa R, Koga M, Nozaki M Nakano H.: "Efficacy of selective venous sampling to localize a small ovarian andorogen-production tumor"J Obstet Gynaccol Res. 25. 231-236 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kaku T, Sonoda K, Kamura T, Hirakawa T, Sakai K, Amada S, Ogawa S, Kobayashi H, Nakashima M, Watanabe T, Nakano H.: "The prognostic significance of tumor-associated antigen 22-1-1 expression in adenocarcinoma of the uterine cervix"Clin cancer Res. 5. 1449-1453 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamura T,Yahata H, et al.: "Is nuclear expression of Y Box-Binding Protein-1 a new prognostic factor in ovarian serous adenocarcinoma?"Cancer. 85. 2450-2454 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakai K,Kaku T,et al.: "Comparison of p53,Ki-67 and CD44v6 expression between primary and matched metastatic lesions in ovarian cancer"Gynecologic Oncology. 72. 360-366 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hirakawa T,Kamura T , et al.: "Prognostic significance of epithelial-stromal vascular cuffing and microvessel density in squamous cell carcinoma of the uterine cervix"Gynecologic Oncology. 74. 369-374 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kamura T,Yahata H, et al.: "Predicting pelvic lymph node metastasis in endometrial carcinoma"Gynecologic Oncology. 72. 387-391 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inoue Y,Kamura T, et al.: "Efficacy of selective-venous sampling to localize a small ovarian androgen-producing tumor"Journal of Obstetrics and Gynecology Research. 25. 231-235 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kaku T,Sonoda K,et al.: "The prognostic significance of tumor-associated antigen-22-1-1 expression in adenocarcinoma of the uterine cervix"Clinical Cancer Research. 5. 1449-1453 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iwasaka T.Kamura T.et al.: "Adjuvant chemotherapy after radical hysterectomy for cervical carcinoma:A compsiron with effects of adjuvant radiotherapy." Obstetrics and Gycecology. 91. 977-981 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sonoda K,Kaku T,Komura T,et al.: "Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasia." Clinical Cancer Research. 4. 1517-1520 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mitsumoto M,Kamura T.et al.: "Emergence of higher levels of invasive and metastatic properties in the drug tesistant cancer cell lines after the repeated administration of cisplatin in tumor-bearing mice." Journal of Cancer Research and Clinical Oncology. 124. 607-614 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shigematsu T.Kamura T.et al.: "Identification of persistent trophoblastic diseases based on a human chorionic gonadotropin regression curve after the evacuation of uneventful moles:by means of a stepwise piecewise linear regression analysis." Gynecologic Oncology. 71. 376-380 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kamura T,Sakai K,et al.: "Comparison of p53 and CD44 variant6 expression between paired primary and recurrent ovarian cancer-An Immunohistochemical Analysis." Oncology Report. 6. 97-101 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kamura T,Yahata H,et al.: "Predicting pelvic lymph node metastasis in endometrial carcinoma." Gynecologic Oncology. (発表予定). (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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