Analysis of Growth Retarded Fetus with Molecular Genetics -Correlation with Genomic Imprinting or Uniparental Disomy-

• Project/Area Number: 09671697
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagasaki University
• Principal Investigator: MASUZAKI Hideaki Nagasaki University, School of Medicine, University Hospital, Lecturer, 医学部附属病院, 講師 (00173740)
• Co-Investigator(Kenkyū-buntansha): JINNO Yoshihiro Nagasaki University, School of Medicine, Associate Professor, 医学部, 助教授 (20179097)
• Project Period (FY): 1997 – 1998
• Project Status: Completed (Fiscal Year 1998)
• Budget Amount: ¥2,700,000 (Direct Cost: ¥2,700,000); Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: IUGR / CPM / UPD / IGF2 / 胎児発育遅延 / ゲノム刷り込み / 片親性ダイソミ- / 分子遺伝学 / confined placental mosaicism

Research Abstract

1) Chromosomal analysis of the amniotic fluid and placenta was performed on forty cases with growth retarded fetus. Confined placental mosaicism(CPM) was found. in four cases(lO%). Placental karyotypes of these four cases were, l)mos 46, XY /50, XY, +2, +7, +15, +20, 2) mos 46, XY/48, XY, +7, +13, 3) mos 46, XY/47, XY, +13 and 4)mos 46, XY/47, XY, +2, respectively.
2) Though molecular analysis was performed in one case with fetus suspected Russell-Silver syndrome, uniparental disomy was not existed.
3) No abnormality was found about IGF2 gene in a placenta associated with fetal growth retardation.