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Clinical roles of plasma phosphatidylcholine hydroperoxide-reducing activity in the development of pre-eclampsia

Research Project

Project/Area Number 09671716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTokai University

Principal Investigator

IWASAKI Katuhiko  Tokai University, School of Medicine, Department of Obsterics and Gynecology, Associate Professor, 医学部, 助教授 (10119646)

Co-Investigator(Kenkyū-buntansha) YOSHIMURA Shinichi  Tokai University, School of Medicine, Department of Molecular Life Science, Assistant Professor, 医学部, 講師 (30230808)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsLipidperoxide / lipid peroxide reducing enzyme / apolipoprotein B100 / Apolipoprotein A1 / Pre-eclampsia / アポリポプロテインA1
Research Abstract

Plasma lipid peroxide has been known as risk factor for atherogenesis, because lipid peroxide attacks endothelial cells. We found that blood plasma possess lipid peroxide reducing activity other than plasma glutathione peroxidase, a major lipid peroxide reducing enzyme. In this study, we initially purified this lipid peroxide reducing protein from human blood plasma and successfully isolated apolipoprotein A1 and B100 as phosphatidylcholine hydroperoxide reducing proteins. In order to clarify the pathophysiological roles of the activity, we have developed an assay method to measure plasma phosphatidylcholine hydroperoxide reducing activity using synthetic 1-pdtoyl-2-nnoleoyl-phosphatidylchonne hydroperoxide (PLPC-OOH) as the substrate. By using this method, PLPC-OOH reducing activity was determined in the plasma of 53 normal pregnancies, 11 patients of pre-eclampsia, 18 pre-stage and 11 high-risk groups for pre-eclampsia. PLPC-OOH reducing activity was greater in the high-risk group than normal pregnancy, while lipid peroxide level was greater in the pre-eclamptic patients. The present results suggested an important role(s) for PLPC-OOH reducing activity in elimination of the plasma lipid hydroperoxide, and further involvement in the development of pre-eclampsia.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] 加藤俊一: "東海大学における臍帯血移植と臍帯血バンク"今日の移植. 10(2). 411-414 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎克彦: "胆嚢癌合併妊娠の一例"日産婦神奈川誌. 34(1). 52-56 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 村野孝代: "Double Catheter法を用いた両側持続硬膜外麻酔によるもやもや病合併妊娠の分娩時麻酔"日産婦神奈川誌. 34(1). 61-64 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小井戸滋: "周産期領域におけるMRIによる胎児診断"日産婦神奈川誌. 34(2). 18-22 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎克彦: "典型的なメイヤー・ロキタンスキー・キュスター症候群の一例"日産婦神奈川誌. 34(2). 62-66 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎克彦: "妊娠に伴う貧血"今月の治療. 6. 767-769 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎克彦: "臍帯血移植における産科医の役割"骨髄バンク. 4. 51-55 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎克彦: "主な合併妊娠の薬物療法の留意点"薬局. 49(9). 25-31 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeyuki Koido: "IgA nephropathy and pregnancy"Tokai J. Exp. Med.. 23(1). 31-37 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ryuichi Mashima: "Reduction of phosphatidylcholine hydroperoxide by apolipoprotein A1: Purification of the hydroperoxide reducing protein from human blood plasma"J. Lipid Res.. 39. 1133-1140 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 牧野英博: "硬膜外麻酔による無痛分娩:無痛ではなく「和痛」を目標に"LiSA. 298. 55-61 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 勝沼潤子: "キニノーゲン・ドメイン3上のフォスファチジールエタノールアミン(PE)結合部の同定"日本産婦人科・新生児血液学会誌. 9(1). 84-85 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ryuichi Mashima: "Reduction of lipid hydroperoxides by Apolipoprotein B-100"Biochem. Biophys. Res. Commun.. 259. 185-189 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎克彦: "多胎妊娠例の帝王切開"周産期医学. 29(7). 835-838 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎克彦: "妊婦のかぜ症候群"周産期医学. 29. 73-77 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 林田研一: "結晶化酸化リン脂質還元活性と妊娠中毒症"産婦人科の世界. 51. 939-943 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katoh S, Yano N, Yano M, Hattori K, Morimoto K, Shimizu T, Hagiwara M, Iwasaki K, Makino T, Tsuji H.: "Transplantation and banking of cord bloods in Tokai University."Transplantation now. 10(2). 411-414 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki K, Koido S, Makino H, Makino H.: "A case of pregnancy complicated with gallbladder carcinoma."Kanagawa Dist. J. Jap. Obest. Gynecol. Soc.. 34(1). 52-56 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Murano T, Makino H, Yasui I, Arai T, Hirasawa T, Koido S, Iwasaki K, Makino T.: "Continuous anesthesia at the parturition of patient with Moya Moya disease using double catheter method."Kanagawa Dist. J. Jap. Obest. Gynecol. Soc.. 34(1). 61-64 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Koido S, Makino H, Iwasaki K, Makino T.: "Fatal diagnosis using MRI in perinatal medicine."Kanagawa Dist. J. Jap. Obest. Gynecol. Soc.. 34(2). 18-22 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki K, Katunoma J, Suzuki T, Makino T.: "A case of typical Meyer-Rochitansky-Cyuster syndrome."Kanagawa Dist. J. Jap. Obest. Gynecol. Soc.. 34(2). 62-66 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki K,: "Anemia complicated with pregnancy."Kongetsunochiryou. 6. 767-769 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki K,: "A role of obsterucian in cord blood transplantation."Kotuzui Bank. 4. 51-55 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki K,: "The problems of the drug therapy on complicated pregnancy."J. Pract. Pharmacol.. 49(9). 25-31 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Koido S, Makino H, Iwasaki K, Makino T.: "IgA nephropathy and pregnancy."Tokai J. Exp. Med.. 23(1). 31-37 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mashima R, Yamamoto Y, and Yoshimura S.: "Reduction of phosphatidylcholine hydroperoxide by apolipoprotein A-1: Puriflcation of the hydroperoxide reducing proteins from human blood plasma."J. Lipid. Res.. 39. 1133-1140 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Makino H, Iwasaki K, Makino T.: "No pain parturition with epidural anesthesia."LiSA. 298. 55-61 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katunuma J, Sugi T, Utida H, Izumi S, Iwasaki K, Makino H.: "Identification of phosphatidyl-ethanolamine binding site on the kininogen domain 3."Jap.J. Obest. Gynecol. Neonat. Heatol.. 9(1). 84-85 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mashima R, Iwasaki K, Yamamoto Y.: "Reduction of lipid hydroperoxide by apolipoprotein B-100"Biochem. Biophys. Res. Commun.. 259. 185-189 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki K,: "Cesarean section of multifatal pregnancy."Perinatal Med.. 29(7). 835-838 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki K,: "Cold syndrome in pregnant women."Perinatal Med.. 29(suppl). 73-77 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayashida K, Iwasaki K, Makino T, Yamamoto Y.: "Plasma phspholipid hydroperoxide reducing activity and pre-eclampsia."The world of Obest. Gynelcol. 51(10). 939-943 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ryuichi Mashima: "Reduction of lipid hydroperoxides by Apolipoprotein B-100"Biochem Biophys.Res.Commun.. 259. 185-189 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 牧野英博: "硬膜外麻酔による無痛分娩:無痛ではなく「和痛」を目標に"LiSA. 298. 55-61 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 勝沼潤子: "キニノーゲン・ドメイン3上のフォスファチジールエタノールアミン(PE)結合部の同定"日本産婦人科・新生児血液学会誌. 9(1). 84-85 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岩崎克彦: "多胎妊娠例の帝王切開"周産期医学. 29(7). 835-838 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岩崎克彦: "妊婦のかぜ症候群"周産期医学. 29(増刊号). 73-77 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 林田研一: "血漿過酸化リン脂質還元活性と妊娠中毒症"産婦人科の世界. 51. 939-943 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岩崎 克彦: "妊娠に伴う貧血" 今月の治療. 6. 767-769 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岩崎 克彦: "臍帯血移植における産科医の役割" 骨髄バンク. 4. 51-55 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岩崎 克彦: "主な合併妊娠の薬物治療の留意点" 薬局. 49(9). 25-31 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shigeyuki Koido: "LgA nephropathy and pregnancy" Tokai J.Exp.Med.23(1). 31-37 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ryuichi Mashima: "Reduction of phosphatidylcholine hydroperoxide by apolipoprotein A1: purification of the hydroperoxide-reducing protein from human blood plasma" J.Lipid Res.39. 1133-1140 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Futoshi Okada: "Inflammatory cell-mediated tumour progression and minisatellite mutant corr-elate with decrease of antioxidant enzymes in murine fibrosarcoma cells." Br.J.Cancer. 79(34). 377-385 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 加藤,俊一: "東海大学における臍帯血移植と臍帯血バンク" 今日の移植. 10・2. 411-414 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小井戸,茂: "周産期領域におけるMRIによる胎児診断" 日産婦神奈川誌. 34・2. 18-22 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] R.Mashima: "Reduction of phosphatidylcholine hydroperoxide by apolipoprotein A-1:Purification of the hydroperoxide-reducing proteins from human blood plasma." J.Lipid Res.(in press). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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