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The cerebral thermo-pooling and hypothermia treatment of perinatal brain damage.

Research Project

Project/Area Number 09671720
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

SUZUKI Shunji  Nippon Medical School OBSTETRICS AND GYNECOLOGY Instructor, 医学部, 助手 (80291722)

Co-Investigator(Kenkyū-buntansha) SAWA Rintaro  Nippon Medical School OBSTETRICS AND GYNECOLOGY Instructor, 医学部, 助手 (30267174)
米山 芳雄  日本医科大学, 医学部, 講師 (00201096)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsFetal sheep / Brain temperature / ADENOSINE / Umbilical cord occlusion / 羊水過少 / 胎子 / プリン代謝産物
Research Abstract

The purpose of this study was to compare core temperatures and brain temperatures after complete but intermittent occlusions of umbilical cord. Thermocouple probes were placed in the para-sagittal parietal cortex, ascending aorta, and jugular vein of eight near-term fetal, sheep and in the maternal descending aorta. Three days later, after an initial control period, the umbilical cord was occluded for 5 min, followed by a 30-min recovery period, and this cycle was repeated 4 times. Temperature changes, blood gases, and plasma glucose, lactate and adenosine were measured. In the first occlusion period, body core temperature increased 0.12 C over control, and then declined to baseline after cord release, and this pattern was repeated with subsequent occlusion. Plasma adenosine increased 2.4-fold during the first occlusion, but not during subsequent occlusion, despite a continuing regulator of cerebral metabolism. We conclude that brain temperature fails to increase because of diminished heat production by the brain and increases in cerebral blood flow, responses which delay complete depletion of adenosine 5Ztriphosphate stores in brain tissue.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Suzuki S: "Prediction of Oligohydramnios in Prolonged Pregnancy" Genecol Obstet Invest. 187(in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki S: "Maternal Plasma Adenosine Levels in Pregnancies complicated by Toxemia" Trophoblast Research. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki S: "Iatroqenic Monoamniotic Twin Gestation with Progressive Twin-twin Transfusion Syndrome" Fetal Diagn Thev. 757(in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sawa R: "Fetal plasma hypoxanthine level in growth-retarded fetuses before labor" Journal of Clinical Endocrirology and Metabolism. 82. 1423-1426 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoneyama Y.: "Evidence for mechanism of the acute phase response to endotoxin in late-gestation fetal goat." American Journal of Obstetrics and Gynecology. 179. 750-755 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kubonoya K: "Brain temperature and metabolic responses during cmbilical cord occlusion in fetal sheep" Pflugers Archiv European Journal of Physiology. 436. 667-672 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki S.et al: "Maternal plasma adenosine levels in pregnancies" Trophoblast research. 11(in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] SAWA, R.et al: "Fetal plasma hypoxanthine level in growth-retarded fetuses before labor" J Clin endocrinol Metab. 82. 1423-1426 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KUBONAYA K.et al: "Brain temperature and metabolic responses during umbilical cord occlusion in fetal sheep" Pflugers Archiv European Journal of Physiology. 436. 667-672 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] YONEYAMA Y.et al: "Evidence for mechanism of the acute phase response to endotoxin in late-gestation fetal goat" Am J Obstet Gynecol. 179. 750-755 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] YONEYAMA Y.et al: "The relationship between uterine artery Doppler velocimetry and umbilical venous adenosine levels in pregncies complicated by preeclampsia" Am J Obstet Gynecol. 174. 267-271 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] SUZUKI S.et al: "Prediction of Oligo-hydramnions in prolonanged pregnancy" Gynecol Obstet Invest. 187 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] SUZUKI S.et al: "Iatrogenic monoamniotic twin gestation with progressive twin-twin transfusion syndrome" Fetal Diagn Research. 757 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki S.: "Prediction of Oligohydramnios in Prolonged Pregnancy" Genecol Obstet Invest. 187 in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suzuki S.: "Maternal Plasma Adenosine Levels in Pregnancies complicated by Toxemia" Trophoblast Research. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suzuki S.: "Iatrogenic Monoamniotic Twin Gestation with Progressive Twin-twin Transfusion Syndrome" Fetal Diagn Ther. 757 in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sawa R.: "Fetal plasma hypoxanthine level in growth-retarded fetuses before labor" Journal of Clinical Endocrirology and Metabolism. 82. 1423-1426 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoneyama Y.: "Evidence for mechanism of the acute phase response to endotoxin in late-gestation fetal goat" American Journal of Obstetrics and Gynecology. 179. 750-755 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kubonoya K.: "Brain temperature and metabolic responses during umbilical cord occlusion in fetal sheep" Pflugers Archiv European Journal of Physiology. 436. 667-672 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] R.Sawa: "Fetal Plasma Hypoxanthine Leve in Growth-Retarded Fetuses Be Pove Labr" Journal ol Clinical Endocrinology and Metabolism. 82・12. 4028-4031 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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