Function on Peyer patch in mother to infant infection with MAIDS virus
| Project/Area Number |
09671728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | NATIONAL INSTITUTE OF INFECTIOUS DISEASE |
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Principal Investigator |
OKADA Yoshiaki NATIONAL INSTITUTE OF INFECTIOUS DISEASE,Dep.Bactero-Blood products Lab. Chief., 細菌・血液製剤部, 室長 (80233352)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | MAIDS virus / Peyer patch / mohter to infant infection / milk / Th2 / neonate / murine AIDS / milk / immunodeficiency / 経口トレランス / マウスエイズウイルス / パイエル板 |
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| Research Abstract |
We have found that MAIDS virus infection through mother to infant causes persistent infection in infant. They developed immunodeficiency with general lymphadenopathy and splenomegaly after long carrier state. In contrast to infant, adult mice develop immediately murin AIDS in 4-5 weeks. We analyzed the mechanism of chronic infection in mother to infant infection in MAIDS virus. We found spleen cells derived from infant showed very weak reaction for ConcanavarineA or anti-CD3 antibody stimulation. Furthermore examination demonstrated poor reactivity owed not antigen presenting cells but T cells. The cytokine production by anti-CD3 antibody stimulation was measured by ELISA.The production dose of gamma-IFN and IL2 war very low, these were parallel to the spleen cells proliferation. But, IL4 was equal to adult. These facts show Th2 is dominant in neonate, contrast to Th1 in adult. We analyzed the effect of the reactivity to the MAIDS virus antigen on adult, when mice had been exposured to them at infant. In adult mice, being Th1 dominant, MAIDS virus antigen can induce the proliferation on naive T cells. But, exposured mice at infant period can not do. Th2 dominant state may induce not acute infection but persistent infection.
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Report
(3 results)
Research Products
(4 results)
