| Project/Area Number |
09671764
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | TOKYO WOMEN'S MEDICAL UNIVERSITY |
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Principal Investigator |
ARAI Yasuko TOKYO WOMEN'S MEDICAL UNIVERSITY,FACULTY ASSISTANT OF MEDICINE,DAINI HOSPITAL,DEPARTMENT OF PROFESSOR OTOLARYNGOLOGY, 医学部, 助教授 (50119880)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Motoko TOKYO WOMEN'S MEDICAL UNIVERSITY,FACULTY ASSISTANT OF MEDICINE,DAINI HOSPITAL,DE, 医学部, 助手 (60297554)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | caloric nystagmus / otolith organ / semicircular-canal-plugging / convection of endolymph / velocity storage / 3D eye recording / monkey / 有毛細胞 / 3次元 / ハト |
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| Research Abstract |
The main source of caloric nystagmus was thought to be convection flow of endolymph in the lateral semicircular canal. However, the active caloric nystagmus in the micro-gravity disclosed the importance of non-convective component
This research dealt with three-dimension analysis of caloric nystagmus before and after all-semicircular-canal plugging in monkeys as a joint research with Professor B.Cohen's group of Mount Sinai Medical Center New York University. We found that 1)all-canal-plugging did not abolish caloric nystagmus, and that 2)the head vertical component of caloric nystagmus in tilted position was spatially fixed before plugging that was changed to be head fixed after plugging and that 3)the spatially vertical component was related to the body vertical component. The success of plugging surgery was confirmed physiologically and also anatomically for the animal fulfilled all scheduled experiments. These results showed that the change of temperature in the inner ear can induce nystagmus without convection flow, yet influenced by gravitational force.
The effect of localized hair-cell lesions of the lateral canal was planned using a small experimental animals (pigeon). To establish the methodology for three-dimension analysis of the freely moving head was not accomplished during this period of time.
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