| Project/Area Number |
09671765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
KOYAMA Mamoru (1998) Nippon Medical School, 医学部, 助手 (60267169)
大塚 博邦 (1997) 日本医科大学, 医学部, 助教授 (80094647)
|
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| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | stem cell factor / allergic rhinitis / epitherial cell / mast cell / allergic shinitis / epithelial cell / mast cell / 鼻粘膜 / 上皮細胞 |
|---|
| Research Abstract |
Inimunohistiochemically, SCF was identified in the nasal epithelium of the biopsy specimens and in cultured nasal epithelial cells. SCF mRNA was exmpressed by cultured nasal epithelial cells not only in patients with allergy. However, the SCF/BETA-actin mRNA ratio and SCF production in day 7 cultured epithelial cells was significantly higher in aller- gic than in nonallergic subjects. SCF production from nasal scrapings in culture was strongly correlated with the number of mast cells and the histamine content.
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