| Project/Area Number |
09671770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Fujita Health University |
|---|
Principal Investigator |
MIWA Masato Fujita Health University, Dept.of Otolaryngology, Assistant Professor, 医学部, 講師 (80247650)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOMORI Mayumi Fujita Health University, Dept.of Otolaryngology, Visiting Assistant Professor, 医学部, 助手
TAKASU Akihiko Fujita Health University, Dept.of Otolaryngology, Associate Professor, 医学部, 助教授 (90140011)
INATA Shigenobu Fujita Health University, Dept.of Otolaryngology, Ex-Professor, 医学部, 教授 (90084558)
|
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| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,800,000 (Direct Cost: ¥2,800,000)
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| Keywords | secretion / choride channel / ciliated epithelial cell / airway / patch clamp / allergy / macrolides / primary culture of epithelial cells |
|---|
| Research Abstract |
The Origin of airway secretion are thought to be composed of seromucous glands, goblet cells, transudation from capillaries secretions and cell debris from leucocytes. We demonstrated that the chloride conductance of tracheal ciliated epithelial cells excised from guinea pigs increases after administration of β-adrenergic, cholinergic and purinergic stimulants based on the patch clamp technique for the first time. We concluded that the pericilliary layers with low viscosity in which cilia beat is possibility formed partly by the ciliated epithelial cell itself.
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