| Project/Area Number |
09671772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KUMAZAWA Hirobumi Kansai Medical University, Department of Otolaryngology, Associate Professor, 医学部, 助教授 (80148519)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Ryouichi Kansai Medical University, Department of Otolaryngology, Assistant, 医学部, 助手 (10319618)
TACHIKAWA Takuya Kansai Medical University, Department of Otolaryngology, Assistant, 医学部, 助手 (30216981)
FUKUMOTO Manabu Tohoku University, Department of Pathology, Professor, 医学部, 教授 (60156809)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Head and neck caricinomas / Gene therapy / Cyclin D1 / サイクリンD1 / 頭頚部扁平上皮癌 / 細胞周期 / サイクリン / 予後因子 / 頭頸部扁平上皮癌 / 遺伝子増幅 / トランスフェクション |
|---|
| Research Abstract |
The grading of biological malignancy was studied in patients with head and neck squamous cell carcinomas. The studies concerning the amplification of the cyclinD1 gene and overexpression of cyclinD1 protein in head and neck squamous cell carcinomas were studied to evaluate the prognostic significance of patients. The amplification of cyclinD1 gene and overexpression of cyclinD1 protein in head and neck squamous cell carcinomas were considered to be useful for assessment of biological malignancy and prognosis in head and neck squamous cell carcinomas. These results suggest the approach for genetherapy using cyclinD1 for patients with head and neck carcinomas.
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