| Project/Area Number |
09671791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
TERASAKI Hiroko Nagoya University, School of Medicine, Professor, 医学部, 教授 (40207478)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Yozo School of Medicine, Professor, 医学部, 教授 (30166136)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | endoscope / fluorescein angiography / indocyanin green angiography / mean circulation time / age-related macular degeneration / diabetic retinopathy / 硝子体手術 / 網膜 / 増殖糖尿病 網膜症 |
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| Research Abstract |
We developed intraoperative fluorescein angiography during vitrectomy using ophthalmic endoscope. We studied the fluorescein findings of extreme retinal periphery and ciliary body which had not been observed by regular fundus camera. First of all, we found that many eyes with proliferative diabetic retinopathy showed unusual findings in the extreme retinal periphery, which correlated the severity of retinal circulatory disturbances. Second, we applied this technique for the inflammatory disease such as bacterial endophthalmitis and uveitis. In bacterial endophthalmitis, the fluorescein findings appeared normal despite the severe functional abnormalities of the retina, which might be reversible retinal damage of inner retina by bacterial endotoxins. In uveitis, the fluorescein angiography revealed the neovascularization at the pars plana of ciliary body during surgery for vitreous hemorrhage which we could treat successfully at the time of surgery. We concluded that the neovascularization could develop during the inflammatory process not associated with vascular occlusion. Third, we successfully analyzed the mean retinal circulation time directly by recording the fluorescein angiography during operation.
In addition to fluorescein angiography, we successfully recorded intraoperative indocyanin green angiography for patients with proliferative diabetic retinopathy and age-related macular degeneration in which we found choroidal new vessels remained frequently even after surgical removal. Age-related macular degeneration has become one of chief cause of blindness which we should continue to fight against with these new techniques.
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