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Electroretinographic study of the inner retinal function

Research Project

Project/Area Number 09671808
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionMiyazaki Medical College

Principal Investigator

NAO-I Nobuhisa  Miyazaki Medical College, Professor, 医学部, 教授 (50211412)

Co-Investigator(Kenkyū-buntansha) CHUMAN Hideki  Miyazaki Medical College, Research Associates, 医学部, 助手 (20244204)
NAKAZAKI Shuji  Miyazaki Medical College, Research Associates, 医学部, 助手 (40291546)
MARUIWA Futoshi  Miyazaki Medical College, Assistant Professors, 医学部, 講師 (70209691)
ARAI Mikki  Miyazaki Medical College, Assistant Professors, 医学部, 講師 (10253832)
中野 徹  宮崎医科大学, 医学部, 講師 (40274774)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsretina / electroretinogram / electrophysiology
Research Abstract

Research in this year consisted of clinical electroretinographic experiment in human and basic animal experiment using retinas of cats and chicks.
We recorded multifocal electroretinogram in glaucoma patients and controls. In glaucoma eyes, each multifocal components reduced and peak latencies increased. However, whether this is the result of dysfunction of inner retinal function remains undetermined.
For M-wave, TTX which suppresses Na-dependent action potential did not have effects on M-wave, but decreased off-response of ERG.On-response of M-wave inverted with intravitreal injection of APB and aspartate abolished it. Sustained negative response of ERG did not change with APB.Thus, M-wave contributed little to regular ERG.
For scotopic threshold response (STR), we could measure the depth profile of this response. STR was maximum in the inner reticular layer and the response was inverted at the 60% retinal depth. This suggested that there is the current sink at the proximal site and the current source at the distal site. Study using potassium-selective microelectrode revealed close relationship between the change in potassium concentration and the electroretinographic change.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 中野, 美智子: "眼底所見の乏しい網膜ジストロフィーの電気生理学的研究" 日本眼科紀要. 48. 482-486 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 横山, 顕子: "網膜円孔の多局所網膜電図" 日本眼科紀要. 48. 841-844 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 横山, 顕子: "黄斑円孔とVERIS" 眼科. 39. 1065-1070 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 新井, 三樹: "電気生理学的検査と緑内障診断" あたらしい眼科. 14. 839-841 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakazaki, Shuji: "Effects of hypoxia and post-hypoxic recovery on chich retinal pigment epithelium potentials and light-evoked responses in vitro" Current Eye Research. 17. 384-391 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagatomo, Akiko: "Multifocal electroretinograms in normal subjects." Japanese Journal of Ophthalmology. 42. 275-280 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Arai, Mikki: "Multicocal electroretinogram indicates visual field loss in acute zonal occult outher retinopathy" Americal Journal of Ophthalmology. 126. 466-469 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kitamura, Keiko: "Effect of irrigating solution on flicker electroretinogram during cataract surgery in human eye" Japanese journal of Ophthalmology. 42. 275-280 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maruiwa, Futoshi: "Effects of bicarbonate ion on chick retinal pigment epithelium : Membrane potentials and light-evoked responses." Vision Resarch. 39. 159-167 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shuji Nakazki, Nobuhisa Nao-i and Atsushi Sawada: "Effects of hypoxia and post-hypoxic recovery on chich retinal pigment epithelium potentials and light-evoked responses in vitro." Curent Eye Research. 17. 384-391 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akiko Nagatomo, Nobuhisa Nao-i, Futoshi Maruiwa, Mikki Arai, Atsushi Sawada: "Multifocal electroretinogarams in normal subjects." Japanese Jouranal of Ophthalmology. 42. 129-135 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mikki, Arai, Nobuhisa Nao-i, Atsushi Sawada and Tadashi Hayashida: "Multifocal electroretinogram indicates visual field loss in acute zonal occult outer retinopathy." American Joural of Ophthalmology. 126. 466-469 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Keiko Kitamura, Nobuhisa Nao-i, Futoshi Maruiwa and Atsushi Sawada: "Effecto of intraocular irrigating solution on flicker electroretinogram during cataract surgery in human eye." Japanese Journal of Ophthalmology. 42. 274-280 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Futoshi Maruiwa, Nobuhisa Nao-i, Shuji Nakazaki, Atsushi Sawada: "Effects of bicarbonate ion on chick retinal pigment epithelium : membrane potentials and light-evoked responses." Vision Research. 39. 159-167 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 直井,信久: "私の選択/黄斑部診断装置-黄斑部多局所網膜電図記録システム" 眼科手術. 10. 56-57 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 横山,顕子: "黄斑円孔の多局所網膜電図" 日本眼科紀要. 48. 841-844 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 横山,顕子: "黄斑円孔とVERIS" 眼科. 39. 1065-1070 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中野,美智子: "眼底所見の乏しい網膜ジストロフィーの電気生理学的研究" 日本眼科紀要. 48. 482-486 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 新井,三樹: "電気生理学的検査と緑内障診断" あたらしい眼科. 14. 837-841 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakazaki, Shuji: "Effects of hypoxia and post-hypoxic recovery on chich retinal pigment epithelimum potentials and litht-evoked responses in vitro" Current Eye Research. 17. 384-391 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagatomo,Akiko: "Multifocal electroretinograms in normal subjects." Japanese Journal of Ophthalmology. 42. 129-135 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Arai,Mikki: "Multifocal electroretinogram indicates visual field loss in acute zonal occult outer retinopathy" American Journal of Ophthalmology. 126. 466-469 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kitamura-Hashiguchi, Keiko: "Effect of irrigating solution on flicker electroretinogram during cataract surgery in human eye." Japanese Journal of Ophthalmology. 42. 275-280 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Maruiwa,Futoshi: "Effects of bicarbonate ion on chick retinal pigment epithelium: Membrane potentials and light-evoked responses" Vision Resarch. 39. 159-167 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] NAKAZAKI,SHUGI: "Effects of Hypoxia and Post-Hypoxic Recovery on Chick Retinal Pigment Epithelium Potentials and Light-Evoked Responses in Vitro" Current Eye Researct. 17(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] ARAI,MIKKI: "Multifocal Electroretinogram Indicates Visual Field Loss in ACute Zonal Occult Outer Retinopathy." American Journal of Ophthalmology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] KITAMURA-HASHIGUCHI,KEIKO: "Effect of irrigating solution on flicker electroretinogram during cataract surgery in human eye." Japanese Journal of Ophthalmology. 42(in press). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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