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Effects of Excimer Laser Radiation on Ocular Tissues

Research Project

Project/Area Number 09671816
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionJuntendo University

Principal Investigator

NAKAYAMA Kiyoo  Juntendo University Ophthalmology, Assistant Professor, 医学部, 助教授 (10124976)

Co-Investigator(Kenkyū-buntansha) KATO Takuji  Juntendo University Ophthalmology, Instructor, 医学部, 助手 (20296875)
ISHIKAWA Takashi  Juntendo University Ophthalmology, Instructor, 医学部, 講師
KANAI Atsushi  Juntendo University Ophthalmology, Professor, 医学部, 教授 (00053059)
HOSODA Yuji  Juntendo University Ophthalmology, Instructor, 医学部, 助手 (80286723)
高橋 康造  順天堂大学, 医学部, 助手
貞松 良成  順天堂大学, 医学部, 助手 (30266019)
清川 正敏  順天堂大学, 医学部, 助手 (00296865)
古川 裕之  順天堂大学, 医学部, 助手 (60286705)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsExcimer laser / Keratectomy / Subepithelial opacity / Descemet's membrane / Extracellular matrix / immunohistochemistry / PCR / corneal wound healing / LASIK / VI型コラーゲン / アスコルビン酸 / 角膜創傷治癒 / コラーゲン / プロテオグリカン / 長期的観察 / 生物活性物質
Research Abstract

1. Excimer laser keratectomy in rabbit
(1) A number of keratocytes which had changed into fibroblastic cells, invaded into the subepithelial area of the ablated cornea. In this area, type III and IV collagens, chondroitin-G-sulfate and large proteoglycan were localized.
(2) Abnormal deposit appeared in Descemets membrane at third day after excimer laser keratectomy and was remained until at least one year after the operation. Immuniohistochemical studies and RT-PCR method revealed that type VI collagen was contained in this deposit.
(3) The healing process of the epithelial brasement membran and subepithelial stroma was still incomplete three years after excimer laser keratectomy.
(4) Excimer laser radiation induced the increase of ascorbic acid in aquaous human 15 minutes after the operation. The clinical meaning of the result was unknown.
2. Mechanical (Conventional) keratectomy in rabbit
The results previously mentioned on 1. (1)(2)(3) were also obtained in the rabbit corneas which received mechanical keratectomy. It seemed that the nonspecific process of wound healing occurred in rabbit cornea which received excimer laser keratectomy.
3. LASIK (laser in situ keratomileusis)
The damage to rabbit corneas induced by LASIK was mild to moderate. However it was very anxious that the wound healing after LASIK was very weak.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (107 results)

All Other

All Publications (107 results)

  • [Publications] Furukawa H. Nakayasu K, Gotoh T. Watanabe Y. Takano T. Ishikawa T. Kanai A: "Effect of topicaltranilast and cortricosteroids on subepithelial haze after photorefractive karetectomy in rabbits."J Refract Surg. 13(suppl). S458-S458 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hotta Y, Kitagawa H. Fujiki K, FUjimaki T. Ohnuki H. Sakuma H. Iwata F. Watanabe M. Nakayasu K. Kanai A: "Plus/Minus Screening of Rabbit Corneal Endothelial cDNA library"Jpn J Ophthalmol. 41. 370-375 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "エキシマレーザー角膜表象切除後の上皮下混濁"日コレ誌. 39(1)補遺. S9-S15 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫、金井淳: "PTK・PRK手術の問題点"眼科. 39. 835-844 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 羽出山勉、海老原伸行、渡部保男、中安清夫、金井淳: "マトリックスメタロプロテアーゼ阻害剤の角膜血管再生抑制効果"日眼会誌. 102(4). 270-275 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujiki K, Hotta Y. Nakayasu K. Kanai A: "Homozygotic Patient with βig-h3 gene mutation in granular dystrophy"Cornea. 17(3). 288-292 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石川隆、平野東、井上淳子、中安清夫、金井淳、竹内邦彦、神田貴之: "眼内レンズパワーの決定と治療的表層角膜切除術眼での変法"日眼会誌. 102. 594-600 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujiki K, Hotta Y. Nakayasu K. Yokoyama T. Takano T. Yamaguchi T. Kanai A: "A new L527R mutation of βIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacities"Human Genet. 103. 286-289 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hotta Y. Fujiki K. Ono K. Fujimaki T. Nakayasu K. Yamaguchi T. Kanai A: "Arg124Cys mutation of the βig-h3 gene in a Japanese family with lattice corneal dystrophy type I"Jpn. J. Ophthalmol. 42. 450-455 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshida H. Nakayasu K. Kanai A: "Effect of cdyclosporin A eyedrops on tear secretion in rabbit"Jpn. J. Ophthalmol. 42. 168-173 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "角膜における細胞外マトリックス「巻頭言」"日眼会誌. 102(4). 223-224 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishii T. Tsunoda K. Otsuka T. Yajima H. Itoh H. Nakayasu K and kanai A: "Applicatioin of excimer laser ablasion to biomaterials: Surface structires of ablated rabbit cornea and collagen film"J. Photopolymer Science and Technology. 11(2). 330-340 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Klintworth GK, Sommer JR, Nakayasu K: "Familial Subepithelial corneal amyloidosis(gelatinous drop-like corneal dystrophy): Exclusion of linkage to lactoferrin gene"Molecular Vision. 4. 43-43 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫、渡部保男、後藤淑子、加藤卓次、石川隆、金井淳: "エキシマレーザー表層切除家兎角膜の創傷治療に関する長期観察"日本眼科学会雑誌. 103(2). 99-107 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 細田裕治、中安清夫: "遠視矯正photorefractive keratectomy後家兎角膜共焦点顕微鏡による観察と組織学的検討"日眼会誌. 103(3). 243-251 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hasegawa N. Torii T. Nagaoka I, Nakayasu K. MIyajima H. Habuchi O: "Measurement of activities of human serum sulforans forases which transfer sulfate to tje galactose residues of keratan sulfate and to the N-acetyllactovamine trisaccaride: Comparison between normal controls and patients with macular corneal dydrophy"J Biochem. 125. 245-252 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 渡部通史、中安清夫、金井淳: "神経伝達物質の家兎角膜に及ぼす影響"日眼会誌. 103(5). 356-362 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐渡一成、井川誠一朗、中安清夫: "各種コンタクトレンズの装用に伴う自覚症状・他覚所見について"日コレ誌. 41(1). 14-25 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 上杉祐子、中安清夫、金井淳: "角膜白斑に対する全層角膜移植"あたらしい眼科. 16(5). 715-719 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kato T. Nakayama K. Ikegami K. Obara T. Kanayama T. Kanai A: "Analysis of glycosaminoglycans in rabbit cornea after excimer laser karatectomy"Br J Ophthalmol. 83. 609-612 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 加藤卓次、中安清夫、金井淳: "家兎全層角膜移植後の角膜創傷治療と細胞外マトリックスに関する免疫組織学的探索"日眼雑誌. 103(7). 519-526 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ebihara N. Yokoyama T. Kimura T. Nakayama T. Kimura T. Nakayasu K. Okumura K. Kanai A,Ra c: "Anti VLA-1 monoclonal antibody inhibits eospnophil infiltration in allergic conjunctivitis model of guanea pig"Current Eye Res. 19(1). 20-25 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 久保慶和、有村秋子、中安清夫、金井淳: "ウサギ結膜組織培養におけるビタミンAパルミテートのムチン産生促進作用"日眼会誌. 103(8). 580-583 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 上杉祐子、長谷川伸子、堀川沙紀、中安清夫: "順天堂医院眼科における15年間の全層角膜移植の術後経過について"順天堂医学. 45(2). 260-268 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 久保慶和、有村秋子、渡部保男、中安清夫、金井淳: "ビタミンA欠乏色飼育家兎に対するビタミンAパルミテートの点眼効果"日眼会誌. 103(10). 729-733 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 細田裕司、中安清夫: "レーザー角膜内切削形成術を施行した家兎角膜の病理所見"日眼会誌. 103(11). 782-789 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "ディスポーザブルコンタクトレンズ"眼科. 41(2). 155-164 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 金井淳、堀川沙紀、大谷園子、黒川真理、中安清夫: "コンタクトレンズと視力矯正 コンタクトレンズ装用による角膜への影響"THE VISIOIN CARE. 54-58 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "不同視による眼精疲労"あたらしい眼科. 16(5). 615-620 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "近視の手術的治療、近視の手術的治療の問題点"医学のあゆみ. 189(7). 463-464 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "質疑応答Q&A 水疱性角膜症の治療"日本医事新報. 3910. 168-169 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "書評コンタクトレンズデータブック2000"日本の眼科. 70(12). 364 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "屈折矯正術の種類"眼科診療Q&A. 25. 140-141 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "涙液関連検査法の実際"日本の眼科. 70(7). 741-744 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "海外医学情報 近視の発症と夜間睡眠中の室内照明"日本の眼科. 70(9). 1055 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 加藤卓次、中安清夫: "特集 角膜移植とアイバンク 結膜移植・輪部移植"眼科診療プラクティス. 51. 58-61 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "眼科手術のトラブルシューティングIV 角膜移植手術のトラブルと対処 3.術後の問題"眼科. 41(10)臨時増刊. 1321-1331 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "角膜移植とアイバンク 前房形成不全への対処"眼科プラクティス. 51. 32 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "シェーグレン症候群"順天堂医学. 45(3). 329-335 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "Eye Surgery Now Illustrated No.3「エキシマレーザー」大橋裕一編"メディカルビュー社. (84-93)10 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 加藤卓次、中安清夫: "Eye Surgery Now Illustrated No.6「水疱性角膜症」大橋裕一編"メディカルビュー社. (124-129)6 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "眼科診療便利手帳 臼井正彦、坪田一男監修"診断と治療社. (88-89)1 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "眼科オピニオン 増田寛次郎総編集、金井淳編集"中山書店. (25-41)16 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanai A. Nakayasu K. Gotoh T: "Myopia Update, Ed. T. Tokoro"Springer. (181-186)6 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 加藤卓次、中安清夫: "眼科オピニオン、インフォームドコンセント、編集:小暮文雄、浜中輝彦"中山書店. (299-301)3 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakayasu K. Kato T. Ebuhara N. Watanabe Y: "Current Opinion in the Kyoto Cornea Club Vol III.. ed. by Kinoshita S. Ohashi Y"Kuglar Publication. (79-94)16 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "Eye Surgery Now Illustrated No.13"メディカルビュー社. (50-53)4 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "基礎と臨床、小出輝、林利彦編"愛智出版. (489-513)25 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中安清夫: "Eye Surgery Now Illustrated No.13"メディカルビュー社. (54-57)4 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakayasu K, Watanabe Y, Gotoh T, Katp T, Ishikawa T, Kanai A.: "Long-terml Healing of Excimer Laser Ablated Rabbit Corneas"Journal of Japanese Ophthalmological Society. 103(2). 99-107 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishii T, Tsunoda K, Otsuka T, Yajima H, Itoh H, Nakayasu K and Kanai A.: "Application of excimer laser ablasion to biomaterials: Surface structures of ablated rabbit cornea and collagen film"J Photopolymer Science and Technology. 11(2). 330-340 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosoda Y, Nakayasu K.: "A Confocal Microscopic and Histological Study on Rabbit Corneas after Photorefractive Keratectomy for Hyperopia"Journal of Japanese Ophthalmological Society. 103(3). 243-251 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kato T, Nakayasu K, Ikegami K, Obara T, Kanayama T, Kanai A.: "Analysis of glycosaminoglycans in rabbit cornea after excimer laser keratectomy"Br J. Ophthalmol. 83. 609-612

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kato T, Nakayasu K.: "Corneal Wound Healing and Immunohistological Features of Extracellular Matrix Following Penetrating Keratoplasty in Rabbits"Journal of Japanese Ophthalmological Society. 103(7). 519-526 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosoda Y, Nakayasu K.: "A Pathological Study on Rabbit Corneas after Laser in Situ keratomileusis"Journal of Japanese Ophthalmological Society. 103(7). 782-789 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakayasu K, Kato T, Ebihara N, Watanabe Y.: "Cell kinetics after penetrating keratoplasty"Current Opinions in the Kyoto Cornea Club ed.by Kinoshita S, Ohashi Y.. Vol.III. 79-94 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishii T, Tsunoda K, Otsuka T, Yajima H, Itoh H, Nakayasu K and Kanai A: "Application of excimer laser ablasion to biomaterials: Surface structires of ablated rabbit cornea and collagen film."J Photopolymer Science and Technology. 11(2). 330-340 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Klintworth GK, Sommer JR, Nakayasu K: "Familial Subepithelial corneal amyloidosis(gelatinous drop-like corneal dystrophy) : Exclusion of linkage to lactoferrin gene."Molecular Vision. 4. 31-43 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 細田裕治、中安清夫: "遠視矯正photorefractive keratectomy 後家兎角膜共焦点顕微鏡による観察と組織学的検討"日眼会誌. 103(3). 243-251 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hasegawa N, Torii T, Nagaoka I, Nakayasu K, Miyajima H, Habuchi O: "Measutemant of activities of Inman serum sulfotrans ferases which transfer sulfate to the galactose residues of keratan sulfate and to the N-acetyl lactovamine trisaccaride: Comparison between normal controls and patients with macular corneal dydtrophy."J Biochem. 125. 245-252 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 渡部通史、中安清夫、金井 淳: "神経伝達物質の家兎角膜に及ぼす影響"日眼会誌. 103(5). 356-362 (1999)

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  • [Publications] 佐渡一成、井川誠一朗、中安清夫: "各種コンタクトレンズの装用に伴う自覚症状・他覚所見について"日コレ誌. 41(1). 14-25 (1999)

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      1999 Annual Research Report
  • [Publications] 上杉祐子、中安清夫、金井 淳: "角膜白斑に対する全層角膜移植"あたらしい眼科. 16(5). 715-719 (1999)

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  • [Publications] Kato T, Nakayasu K, Ikegami K, Obara T, Kanayama T, Kanai A: "Analysis of glycosaminoglycans in rabbit cornea after excimer laser keratectomy."Br J, Ophthalmol. 83. 609-612 (1999)

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  • [Publications] 加藤卓次、中安清夫、金井 淳: "家兎全層角膜移植後の角膜創傷治癒と細胞外マトリックスに関する免疫組織学的検索"日眼雑誌. 103(7). 519-526 (1999)

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  • [Publications] Ebihara N, Yokoyama T, Kimura T, Nakayasu K, Okumura K, Kanai A, Ra C: "Anti VLA-4 monoclonal antibody inhibits eospnophil infiltration in allergic conjunctivitis model of guanea pig."Current Eye Res. 19(1). 20-25 (1999)

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      1999 Annual Research Report
  • [Publications] 久保慶和、有村秋子、中安清夫、金井 淳: "ウサギ結膜組織培養におけるビタミンAパルミテートのムチン産生促進作用"日眼会誌. 103(8). 580-583 (1999)

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  • [Publications] 上杉祐子、長谷川伸子、堀川沙紀、中安清夫: "順天堂医院眼科における15年間の全層角膜移植の術後経過について"順天堂医学. 45(2). 260-268 (1999)

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  • [Publications] 久保慶和、有村秋子、渡部保男、中安清夫、金井淳: "ビタミンA欠乏食飼育家兎に対するビタミンAパルミテートの点眼効果"日眼会誌. 103(10). 729-733 (1999)

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  • [Publications] 細田裕司、中安清夫: "レーザー角膜内切削形成術を施行した家兎角膜の病理所見"日眼会誌. 103(11). 782-789 (1999)

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  • [Publications] 中安清夫: "ディスポーザブルコンタクトレンズ"眼科. 41(2). 155-164 (1999)

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  • [Publications] 金井 淳、堀川沙紀、大谷園子、黒川真理、中安清夫: "コンタクトレンズと視力矯正 コンタクトレンズ装用による角膜への影響"THE VISION CARE. 54-58 (1999)

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  • [Publications] 中安清夫: "不同視による眼精疲労"あたらしい眼科. 16(5). 615-620 (1999)

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  • [Publications] 中安清夫: "近視の手術的治療.近視の手術的治療の問題点"医学のあゆみ. 189(7). 463-464 (1999)

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  • [Publications] 加藤卓次、中安清夫: "屈折矯正手術 エルビウムヤグレーザー"眼科診療Q&A. 24. 1208-1209 (1999)

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  • [Publications] 中安清夫: "質疑応答Q&A.水疱性角膜症の治療"日本医事新報. 3910. 168-169 (1999)

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  • [Publications] 中安清夫: "あゆみTopics : 近視の手術的治療の問題点"医学のあゆみ. 189(7). 464-467 (1999)

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  • [Publications] 中安清夫: "屈折矯正術の種類"眼科診療Q&A. 25. 140-141 (1999)

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  • [Publications] 中安清夫: "海外医学情報. 近視の発症と夜間睡眠中の室内照明"日本の眼科. 70(9). 1055 (1999)

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  • [Publications] 中安清夫: "書評コンタクトレンズデータブック2000"日本の眼科. 70(12). 364 (1999)

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  • [Publications] 中安清夫: "涙液関連検査法の実際"日本の眼科. 70(7). 741-744 (1999)

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  • [Publications] 中安清夫: "特集角膜移植とアイバンク.前房形成不全への対処"眼科診療プラクティス. 51. 58-61 (1999)

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  • [Publications] 加藤卓次、中安清夫: "特集角膜移植とアイバンク.結膜移植・輪部移植"眼科診療プラクティス. 51. 58-61 (1999)

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  • [Publications] 中安清夫: "眼科手術のトラベルシューティング.IV角膜移植手術のトラブルと対処3.術後の問題"眼科. 41(10)臨時増刊. 1321-1331 (1999)

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  • [Publications] 中安清夫: "角膜移植とアイバンク.前房形成不全への対処"眼科プラクティス. 51. 32 (1999)

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  • [Publications] 中安清夫: "シェーグレン症候群"順天堂医学. 45(3). 329-335 (1999)

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  • [Publications] 中安清夫: "眼科診療便利手帳.臼井正彦、坪田一男監修"診断と治療社. (88-89)1 (1998)

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  • [Publications] 中安清夫: "眼科オピニオン 増田寛次郎総編集、金井 淳編集"中山書店. (25-41)16 (1998)

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  • [Publications] Kanai A, Nakayasu K, Gotoh T: "Myopia Update, Ed. T. Tokoro"Springer. (181-186)6 (1998)

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  • [Publications] 加藤卓次、中安清夫: "眼科オピニオン. インフォームドコンセント. 編集:小暮文雄、浜中輝彦"中山書店. (299-301)3 (1998)

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  • [Publications] Nakayasu K, Kato T, Ebihara N, Watanabe Y: "Current Opinions in the Kyoto Cornea Club Vol III. ed. by Kinosira S, Ohashi Y"Kugler Publications. (79-94)16 (1999)

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  • [Publications] 中安清夫: "Eye Surgery Now Illustrated No 13."メディカルビュー社. (54-57)4 (1999)

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  • [Publications] 中安清夫: "Eye Surgery Now Illustrated No 13."メディカルビュー社. (54-57)4 (1999)

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  • [Publications] 中安清夫: "基礎と臨床. 小出輝、林利彦編"愛智出版. (489-513)25 (2000)

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  • [Publications] 中安清夫: "巻頭言 角膜における細胞外マトリックス" 日本眼科学会雑誌. 102(4). 223-224 (1998)

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  • [Publications] 石川隆、中安清夫、他: "眼内レンズパワーの決定と治療的表層角膜切除術眼での変法" 日本眼科学会雑誌. 102. 594-600 (1998)

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  • [Publications] 中安清夫、他: "エキシマレーザー表層角膜切除家兎角膜の創傷治癒に関する長期観察" 日本眼科学会雑誌. 103(2). 99-107 (1999)

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  • [Publications] 加藤卓次、中安清夫: "屈折矯正平衡、エルビウムヤグレーザー" 眼科治療Q&A. 24. 1208-1209 (1999)

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  • [Publications] 細田祐治、中安清夫、他: "遠視矯正PRK後家兎角膜の共焦点顕微鏡による観察と組織学的検討" 日本眼科学会雑誌. 103(3). (1999)

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  • [Publications] Kato T, Nakayasu K, et al.: "Analysis of glycosaminoglycans in rabbitcornea after excimer laser keratectomy" Br.J.Ophthalmol. (予定). (1999)

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  • [Publications] 中安清夫: "眼科オピニオン コンタクトレンズの歴史と他の屈折矯正法との比較" 中山書店, 16 (1998)

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  • [Publications] Kanai A, Nakayasu K, et al.: "Myoria Update Aistochemical and Immunohistochemical studies of rabbit corneas after photorefractive keratectomy" Sprigen-Verlag, 6 (1998)

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  • [Publications] 加藤卓次、中安清夫: "Eye surgery Now Illustrated No6 内皮創傷治療機転" メディカルビュー社, 6 (1998)

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  • [Publications] Furukawa,Y: "Effect of topical tranilast and corticosteroids on subepithelial haze after PRK in rabbits" J.Refract.Surg.13(5). S457-S458 (1997)

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  • [Publications] 中安清夫: "エキシマレーザー角膜表層切除後の上皮下混濁" 日本コンタクトレンズ学会誌. 39(1). S9-S15 (1997)

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  • [Publications] 中安清夫: "PTK、PRK手術の問題点" 眼科. 39(7). 835-844 (1997)

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  • [Publications] 中安清夫: "Eye Surgery Now Illustrated No.3「エキシマレーザー」" メディカルビュー社, 154 (1997)

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Published: 1997-04-01   Modified: 2016-04-21  

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