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Effect of calcitonin gene-related peptide (CGRP) on testicular descent in grnitofemoral nerve divided rats.

Research Project

Project/Area Number 09671832
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 小児外科
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

SHONO Takeshi  Kyushu University, Pediatric Surgery, Senior Registra, 医学部, 講師 (30235717)

Co-Investigator(Kenkyū-buntansha) SUITA Sachiyo  Kyushu University, Pediatric Surgery, Professor, 医学部, 教授 (30038856)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordscryptorchidism / rat / calcitonin gene-related peptide / genitofemoral nerve / カルチトニン遺伝子関連ペプチド
Research Abstract

Testicular descent was inhibited in rats which were performed the division of genitofemoral nerve (GEN) n neonatal period. At 60-90 days old, cryptorchidism was occurred in about 76% in rats which were performed the division of genitofemoral nerve in neonatal period, However, the occurrence of cryptorchidism was significantly decreased in 30-days-old rats which were first performed neonatal GFN division and 20mu gof CGRP was injected subcutaneously in hemiscrotum on operated side from 3to 14 days old. CGRP has been known one of neuropeptide and is released from the terminal of the GFN to mediated the inguinoscrotal testicular descent.
These results suggested that the CGRP might be important peptide to induce normal testicular descent and might be used as effective regimen for the cryptorchidism.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Imajima T,Shomo T et al: "Prenatal phthalate causes cryptorchidism postnatally by inducing the transabdominal ascent of the testis in fetal rats." J Pediatr Surg. 32. 18-21 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zakaria O,Shono T et al: "Fertility and histological studies in a unilateral cryptorchid rat model during early and late adulthood." Br J Urol. 82. 404-407 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zakaria O,Shono T,et al: "Fertility and histological studies of the contralateral testes in two different intra- and extra-abdominal rat models rat models of unilateral cryptorchidism." Br J Urol.82. 574-577 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,et al: "Pubertal genitofemoral nerve division induces testicular ascent in adult rats." J Pediatr Surg. 34. 346-348 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,et al: "Does maternal stress induce a abnormal descent of the testis in prepubertal rats?" Br J Urol. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,et al: "Does Proximal Genitofemoral Nerve Division Induce Testicular Maldescent or Ascent in Rat?" Br J Urol. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,et al: "Proceeding of the Ninth Fukuoka International Symposium on Perinatal Medicine" Maternity and Perinatal Care Unit,Kyushu University Hospital, 87 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 生野 猛、他: "周産母子センター草子.第3巻" 九州大学医学部附属病院周産母子センター, 120 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Imajima T,Shono S,Zakaria O,Suita S: "Prenatal phthalate causes cryptorchidism postnatally by inducing the transabdominal ascent of the testis in fetal rats" J Pediatr Surg. 32. 18-21 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zakaria O,Shono T,Imajima T,Suita: "Fertility and histological studies in a unilateral cryptorchid rat model during early and late adulthood" Br j Urol. 82. 404-407 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zakaria O,Shono T,Imajima T,Suita S: "Fertility and histological studies of the contralateral testes in two different intra- and extra-abdominal rat models of unilateral cryptorchidism" Br J Urol. 82. 574-577 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,Zakaria O,Imajima T, Suita S,Morimoto K: "Pubertal genitofemoral nerve division induces testicular ascent in adult rats" J Pediatr Surg. 34 (2). 346-348 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,Zakaria O,Imajima T,Suita S: "The mechanism of testicular descent" Jpn J Pediatric Surgery. 30 (6). 568-573 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zakaria O,Shono T,Imajima T,Suita S: "Comparative studies of the fertility and histological development of the contralateral scrotal testes in two different rat models of unilateral cryptorchidism" Pediatr Surg Int. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,Zakaria O,Imajima T,Suita S: "Does Proximal Genitofemoral Nerve Division Induce Testicular Maldescent or Ascent in Rat?" Br J Urol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shono T,Zakaria O,Imajima T,Suita S: "Does maternal stress induce a abnormal descent of the testis in prepubertal rats?" Br J Urol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Imajima T, Shono T et al: "Prenatal phthalate causes cryptorchidism postnatally by inducing the transabdominal ascent of the testis in fetal rats." J Pediatr Surg. 32. 18-21 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zakaria O,Shono T et al: "Fertility and histological studies in a unilateral cryptorchid rat model during early and late adulthood." Br J Urol. 82. 404-407 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zakaria O,Shono T et al: "Fertility and histological studies of the contralateral testes in two different intra- and extra-abdominal rat models of unilateral cryptorchidism." Br J Urol. 82. 574-577 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shono T, et al: "Pubertal genitofemoral nerve division induces testicular ascent in adult rats." J Pediatr Surg. 34. 346-348 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shono T, et al: "Does maternal stress induce a abnoraml descent of the testis in prepubertal rats?" Br J Urol. 30(in press). 14-19 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shono T, et al: "Does Proximal Genitofemoral Nerve Division Induce Testicular Maldescent or Ascent in Rat?" Br J Urol. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Shono T, et al: "Procceding of the Ninth Fukuoka International Symposium on Perinatal Medicine" Metarnity and Perinatal Care Unit, Kyushu University Hospital, 87 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 生野 猛、他: "周産母子センター草子.第3巻" 九州大学医学部附属病院周産母子センター, 120 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zakaria O,Shono T,et al: "Comparative studies of the fertility and histological development of the contralateral scrotaltestis in two different rat models of unilateral cryptorchidism." Pediatr.Surg.Int.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Imajima T,Shono T,et al: "Prenatal phthalate causes cryptorchidism postnatally by inducing the transabdominal ascent of the testis in fetal rats." J Pediatr Surg. 32. 18-21 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shono T,et al: "Extra-abdominal fixation of the gubernaculum inhibits testicular descent in newborn rats." J Pediatr Surg. 31. 503-506 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shono T,et al: "Scanning EM shows inhibited gubernacular development in relation to undescended testes in oestrogen-treated mice." Internal Journal of Andrology. 19. 263-270 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shono T,et al: "Extra-abdominal fixation of the gubernaculum inhibits testicular descent in newborn rats." J Pediatr Surg. 31. 503-506 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shono T,et al: "The effect of the excision of future scrotal skin on testicular descent in neonatal rats.-A new experimental model of cryptorchidism." J Pediatr Surg. 30. 734-739 (1995)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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