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Effect of attentional shift on cortical nociceptive neuronal activity in monkeys

Research Project

Project/Area Number 09671907
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionNihon University

Principal Investigator

SUMINO Rhyuji  Nihon University School of Dentistry Professor, 歯学部, 教授 (40014378)

Co-Investigator(Kenkyū-buntansha) TSUBOI Yoshiyuki  Nihon University School of Dentistry Lecturer, 歯学部, 講師 (50246906)
IWATA Koichi  Osaka University Faculty of Dentistry Associate Professor, 歯学部, 助教授 (60160115)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsprimary somatosensory cortex / cingulate gyrus / detection task / monkey / 大脳皮質第一次体性感覚野 / 注意 / 前帯状回
Research Abstract

Functional role of the primary somatosensory cortex and anterior cingulate cortex for processing nociception was studied in awake behaving monkeys. About a half of nociceptive neurons recorded from the primary somatosensory cortex increased their firing frequency following decrease in detection latency according to the change in tooth pulp stimulus intensity, suggesting that these neurons would be involved n sensory discriminative aspect of tooth pulp sensation. However, others were not change in their firing ccording to their detection latency. Thus, the function of these neurons for tooth pulp sensation was unclear. Furthermore, cooling of the primary somatosensory cortex induced an increment of detection latency to heat stimulation and increment of escape behavior. Thesesuggest that primary somatosensory cortex would be involved in modulation of nociception at the level of the medulla or more lower levels as well as nociception. However, the central mechanism of pain modulation produced by cortical cooling was completely unknown. On the other hand, the studies for the functional role of an anterior cingulate gyrus on nociception have been done by some researchers and a little is known. Our data revealed that some nociceptive neurons in the anterior cingulate gyrus decreased their firing frequency after change in their attention from heat to nonnoxious stimulus (light). This exactly suggest that nociceptive neurons in the anterior cingulate gyrus is modulated their activity by attentional shift.
The purpose of the present study was clarifying the mechanism of how the nociceptive information was modified to a pain sensation. Many things are still remained unknown. Human PET study may be helpful to solve this question as well as an awake behaving monkey study.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Rhyuji Sumino: "Behavioral modulation of tooth-pulp sensory responses in monkeys." Dentistry in Japan. 34. 32-36 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koichi Iwata: "Responses of ACCx nociceptive neurons in awake behaving monkeys." Pain Research. 13(1). 15-19 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koichi Iwata: "Primary somatosensory cortical neuronal activity during the monkey's detection of the perceived change in tooth pulp stimulus intensity." Journal of Neurophysiology. 79(4). 1717-1725 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koichi Iwata, Yoshiyuki Tsuboi, Rhyuji Sumino: "Primary somatosensory cortical neuronal activity during the monkey's detection of the perceived change in tooth pulp stimulus intensity." Journal of Neurophysiology. 79(4). 1717-1725 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koichi Iwata, Yoshiyuki Tsuboi, Tohru Sakanashi, Takuro Sekiguchi & Rhyuji Sumino: "Responses of ACCx nociceptive neurons in awake behaving monkeys." Pain Research. 13(1). 15-19 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Rhyuji Sumino, Yoshiyuki Tsuboi, Susumu Hagiwara, Masako Kohno & Koichi Iwata: "Behavioral modulation of tooth-pulp sensory responses in monkeys." Dentistry in Japan. 34. 32-36 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ryuji Sumino: "Behavioral modulation of tooth-pulp sensory responses in monkeys." Dentistry in Japan. 34. 32-36 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koichi Iwata: "Responses of ACCx nociceptive neurons in awake behaving monkeys." Pain Research. 13(1). 15-19 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koichi Iwata: "Primary somatosensory cortical neuronal activity during the monkey's detection of the perceived change in tooth pulp stimulus intensity." Journal of Neurophysiology. 79(4). 1717-1725 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岩田幸一: "Responses of ACCx nociceptive neurons in awake behaving monkeys." Pain Research. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 角野隆二: "Behavioral modulation of tooth pulp sensory responses in monkeys." Dentistry in Japan. 34(印刷中). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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