| Project/Area Number |
09671922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
FUJITA Minoru Hiroshima University, Dental School, Associate Professor, 歯学部, 助教授 (90116658)
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| Co-Investigator(Kenkyū-buntansha) |
OHTANI Keiko Hiroshima University, Dental School, Research Associate, 歯学部, 助手 (20243587)
AKAGI Yukio Hiroshima University, Medical Hospital, Research Associate, 医学部・附属病院, 助手 (40222509)
HIROKAWA Yutaka Hiroshima University, Medical School, Associate Professor, 医学部, 助教授 (40116653)
NAITO Kumiko Hiroshima University, Dental School, Research Associate, 歯学部, 助手 (10155632)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | RADIATION THERAPY / HYPERFRACTIONATION / ORAL CANCER / CHEMOTHERAPY |
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| Research Abstract |
To improve treatment results of radiotherapy for oral cancers, a clinical trial of hyperfractionated radiotherapy with chemotherapy was conducted. Seventy three patients with previously untreated and biopsy-proven squamous cell carcinoma of the oral cavity were entered in the study. The 2-year survival rate of T1 and T2 was high, 82.0%, because of contribution of sa1vage operation. There was not any findings which improved survival rates by hyperfractionated radiotherapy alone. However, combined chemotherapy seemed to improve local control rates than radiotherapy alone treatment. A higher local control rate was obtained in the patients with lower stages of tumors, and it was considered in the standpoint of organ preservation that a smaller size of gaingival or buccal carcinoma should be an indication for hyperfractionated radiotherapy combined with chemotherapy. On the contrary, a local control rate of advanced diseases was the same as that of previously published data. In the treatment of these tumors, radiotherapy should be used in preoperative sense. Volume reduction of tumors by radiotherapy will make a radical operation possible and it may provide a higher local control rate. The grade of acute mucosal reaction was severer than that in the hyperfractionated radiotherapy alone and a split of 1-2-weeks was needed. The incidence of late complications might be higher. Those were radiation osteomyelitis and osteoradionecrosis. In most patients who received 70 Gy or more, the widening of periodontal space was observed. These complications may affect adversely a QOL of patients after treatment. The close management for the oral health was necessary in the patients and it is the forecoming subject in our study.
Alteration of total dose and modifications of both combination and dosage of chemotherapy would be a subject which should be disclosed as quickly as possible.
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