MECHANISMS OF GINGIVAL OVERGROWTH

Research Project

Project/Area Number	09671968
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Conservative dentistry
Research Institution	NIHON UNIVERSITY
Principal Investigator	MURAI Seidai NIHON UNIVERSITY SCHOOL OF DENTISTRY PROFESSOR, 歯学部, 教授 (50059185)
Co-Investigator(Kenkyū-buntansha)	SUGANO Naoyuki NIHON UNIVERSITY SCHOOL OF DENTISTRY FACULTY, 歯学部, 助手 (30246904)
Project Period (FY)	1997 – 1998
Project Status	Completed (Fiscal Year 1998)
Budget Amount *help	¥3,100,000 (Direct Cost: ¥3,100,000) Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000) Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywords	GINGIVAL OVER GROWTH / CYCLOSPORINA / AP-1 / JNK / COLLAGENASE / 歯肉増殖 / 線維芽細胞 / サイクロスポリン
Research Abstract	Cyclosporin A (CsA) has reached significant use as an immunosuppressant to prevent organ transplant rejection because of its suppresive action on T-cells. A frequent side effect of CsA administratoin is gingival overgrowth. As yet, the molecular mechanisms of CsA induced gingival overgrowth are unknown although it has been postulated that CsA affects on LPS induced fibroblastic activity which results in increased extracellular matrix. Therefore, purpose of this study was to determine whether CsA is able to affect signal-transduction of LPS-induced collagenase expression in fibroblast. Our data indicate that CsA downregulate collagenase mRNA expression by fibroblast probably occurs through the AP-l and JNK inhibition. We suggest that inhibitory effects of CsA on LPS induced signal transduction may be implicated in CsA induced gingival overgrowth and mechanisms by which CsA could function as an antiinflammatory agent.