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Effects of Hypercholesterolemic Diet and Occlusal Trauma on the Mandible of Osteoporotic Rats

Research Project

Project/Area Number 09672029
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionFukuoka College of Health Sciences

Principal Investigator

HIDAKA Saburo  Fukuoka Coll Heal Sci, Dental Hygiene, Prof, 歯科衛生学科, 教授 (00084252)

Co-Investigator(Kenkyū-buntansha) YAMADA Yuji  Fukuoka Dent Coll, 1st Dent Surg, Assit Prof, 歯学部, 助手 (60269040)
OGATA Toshihiro  Fukuoka Coll Heal Sci, Dental Hygiene, Associ.Prof, 歯科衛生学科, 助教授 (40140876)
OKAMOTO Yoshizo  Fukuoka Dent Coll, Dental Mater, Lect., 歯学部, 講師 (50084249)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
KeywordsOsteoporosis / Amargam filling / Hypercholesterolemic diet / Mandible / Occlusal Trauma / Rats / Artericsclerosis / 骨密度
Research Abstract

Effects of oodusalstress (OS) on both the periodontium and the tibia in ovariectomized rats fed with hypercholesterolemic diet (HC) were studied Alter fifteen-week feeding the tibial bone mineml density (BMD) in ovariectomized (OVX) rats decreased by 27% from that in sham-operated (sham) rats. But, there were no effects by HC diet and OS on the BMD.The bcne mineral content (BMC) of the mandibular candyle in OVX rats was similar to Sham rats. Also, there were ro effect by HO and OS.However the scanniing electron microsopic (SEM) ana1yses revealed that the periodontal ligament of the OVX rats and the OVX rats given OS became more coarse than that of the Sham rats or the rat treated with 17 beta-estradiol. The surface of the alveolar bone in the OVX rats appeared to contain numerous small granules, whichh were not present in the Sham rats and the rats treated with 17 beta-estradio1. Thus, it was found that * caused alterations in the periodontium and the surface architecture of the alveolarbones. These results suggest that the OS may affect to deterirate the peridontal a1terations and the HC diet may affect to delay the recovery.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Elovic R.P.et al.: "Maxillary molar extraction decreases stiffness of the mandible on ovariectomized rats." J Dent Res. 56. 305-310 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Halser C.M.et al.: "Exercise attenuates diet-induced arteriosclerosis in the adult rats." J Nutri. 117. 986-993 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hidaka S..et al.: "Preventive effects of traditional Chinese (Kampo) medicines on experimental osteoporsis induced by ovariectomy in rats." Calcif Tissu Int. 61. 239-246 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kalu D N.: "The ovariectomized rat model for postmenopusal bone loss." Bone Miner. 15. 175-192 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Lassila V and Koivumaa K.K.: "Deteriorating effect of occlusal disorders on the periodontium of rats with experimental arteriosclerosis." Acta Odont Scand. 38. 41-50 (1979)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumoto C et al.: "Metacarpal bone mass in normal and osteoporotic Japanese women using computed X-ray densitometry." Calcif.Tissue Int.55. 324-329 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka M.et al.: "The effect of aging and ovariectomy on mandibular condyle in rats." J Prosthet Dent. 79. 685-690

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wronsky T.J.: "The ovariectomized rat as an animal model for postmenopausal bone loss." Cells Mater. (Supp 1) 69. 69-74 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato H, Ohki M, Kitamori H.: "A method for quantifying positional change of the condyle on lateral tomograms by means of digital subtraction." J Oral Rehabilitation. 25(6). 448-455 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 佐藤 博信,大喜 雅文,石川 雅嗣,右近 晋一: "オクルーザルピボットの付与により生じる顎関節の負荷-顎関節断層エックス線写真による評価-" 日本補綴歯科学会雑誌42(100回特別号). 84. 84 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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