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Human papilloma virus and oncogene in multi-occurence and recurrence of oral carcinoma

Research Project

Project/Area Number 09672074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

HONMA Yoshiro  Kanagawa Dental College, Dental school, lecture, 歯学部, 講師 (60157112)

Co-Investigator(Kenkyū-buntansha) MIZUNUMA Hideyuki  Kanagawa Dental College, Dental school, assistant, 歯学部, 助手 (70267516)
KAWAHARA Kenji  Kanagawa Dental College, Dental school, assistant, 歯学部, 助手 (80247311)
INOUE Satoshi  Kanagawa Dental College, Dental school, assistant, 歯学部, 助手 (50139557)
OZONO Satoru  Kanagawa Dental College, Dental school, lecture, 歯学部, 講師 (40084785)
KINOSHITA Yukihiko  Kanagawa Dental College, Dental school, associate Professer, 歯学部, 助教授 (70084770)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsoral carcinoma / precancerous lesion / Human Papilloma Virus / proto-oncogene / multi-primary carcinoma / precancerous condition
Research Abstract

1. Multi-primary oral squamous cell carcinoma was encountered predominantly in women, and it was commonly localized in the buccal mucosa and the gingiva. The subsequent appearance of a third group of the lesions commonly represented on early cancer which tented to develop after a shorter time interval.
2. As a background factor, the presence of precancerous lesion was predominant as observed in 7 patients (luekoplakia in 6 and erythroplakia in 1), and 3 patients had a precancerous condition (lichen planus in 2 and, plummer-Vinson syndrome in 1). Linkage to alcohol use or smoking habits was not clear.
3. Histopathologically, epithlial hyperplasia and severe dysplasia were observed in the epithelium of precancerous lesions and in the adjacent epithelium of carcinoma. Immunohistochemical investigation showed HPV16 frequ-ently, and HPV16 was localized commonly in the upper layers to the spinous cells.
4. Electron microscopy revealed 50- to 60-nm viral particles in the epithelial nuclei in precancerous lesions and in the adjacent epithlium of carcinoma. The viral particles were identified to be HPV16 by immuno-electron microscopy.
5. PCR assay revealed that HPVI6 DNA was detected in 7out of 9 patients in the tumor.
These results suggest that HPV16 infected oral mucosa has a potential for multi-occurence of malignant tumor igenesis.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

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