Correlation to the chemosensitivity test and metallothionein immunostaining in head and neck squamous cell carcionoma
| Project/Area Number |
09672079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
MURAMATSU Yasunori Asahi University, School of Dentistry, Lecturer, 歯学部, 講師 (30247556)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | squamous cell carcinoma / head and neck lesion / metallothionein / chemosensitivity test / cisplatin / Immunohistochemistry / 感受性試験 |
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| Research Abstract |
The present study dealts with correlation to the chemosensitivity test and immunohistochemical scoring of metallothionein (MT) in a total 36 cased of squamous cell carcinoma in the oral cavity (n=23), pharynx (n=3), maxillary sinus (n=3), larynx (n=6) and esophagus (n=1). Mainly, chemosensitivity drug test were testing cisplatin (CDDP).
Immunohistochemical evaluation of MT reaction in squamous cell carcinoma in the oral cavity has already been described including scoring of MT index that MT positive cell SCC localized either tumor cell or stromal cell. The study also notes correlation among CDDP sensitivity test and MT profiles and index including clinical outcom, pathological grading and chemotherapy with cisplatin or carboplatin and also radiation therapy. MT Immunoreactivity was expressed both tumor cell cytoplasm and nuclei, and showed heterogeneous localization In tuor epithelial cells and In the stroma. Histiocytic and fibrocytic cells in both peripheral and interstitial stromas were also not stained homegeneously.
CDDP inhibition index (II) showed 50% or higher (n=17) that were sensitivity cases and 19 cases were less than 50% that were no sensitivity cases. MT positive cell index (PI), 14 cases were showed 15% or higher that were immunoreactivity cases and 22 cases were less than 15% that were no reactivity cases. In these, MT PI 15% or higher and CDDP II less than 50% were II cases, MTPI less than 15% and CDDP II 50% or higher were 14 cases. These finding suggest that correlation with CDDP drug sensitivity and MT immunoreactivity case were 25 of 36% cases (69.4%).
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Report
(4 results)
Research Products
(13 results)
