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Correlation to the chemosensitivity test and metallothionein immunostaining in head and neck squamous cell carcionoma

Research Project

Project/Area Number 09672079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionAsahi University

Principal Investigator

MURAMATSU Yasunori  Asahi University, School of Dentistry, Lecturer, 歯学部, 講師 (30247556)

Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordssquamous cell carcinoma / head and neck lesion / metallothionein / chemosensitivity test / cisplatin / Immunohistochemistry / 感受性試験
Research Abstract

The present study dealts with correlation to the chemosensitivity test and immunohistochemical scoring of metallothionein (MT) in a total 36 cased of squamous cell carcinoma in the oral cavity (n=23), pharynx (n=3), maxillary sinus (n=3), larynx (n=6) and esophagus (n=1). Mainly, chemosensitivity drug test were testing cisplatin (CDDP).
Immunohistochemical evaluation of MT reaction in squamous cell carcinoma in the oral cavity has already been described including scoring of MT index that MT positive cell SCC localized either tumor cell or stromal cell. The study also notes correlation among CDDP sensitivity test and MT profiles and index including clinical outcom, pathological grading and chemotherapy with cisplatin or carboplatin and also radiation therapy. MT Immunoreactivity was expressed both tumor cell cytoplasm and nuclei, and showed heterogeneous localization In tuor epithelial cells and In the stroma. Histiocytic and fibrocytic cells in both peripheral and interstitial stromas were also not stained homegeneously.
CDDP inhibition index (II) showed 50% or higher (n=17) that were sensitivity cases and 19 cases were less than 50% that were no sensitivity cases. MT positive cell index (PI), 14 cases were showed 15% or higher that were immunoreactivity cases and 22 cases were less than 15% that were no reactivity cases. In these, MT PI 15% or higher and CDDP II less than 50% were II cases, MTPI less than 15% and CDDP II 50% or higher were 14 cases. These finding suggest that correlation with CDDP drug sensitivity and MT immunoreactivity case were 25 of 36% cases (69.4%).

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Y.Muramatsu, A.Kamegai et al: "Histochemical characteristics of calcium binding S100 proteins and bone morphogenetic proteins in chondro-osseous tumors"Oncology Reports. 4. 849-853 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Muramatsu, A.Kamegai et al: "Novel Ca^<2+>-binding S100 Proteins, Glial Fibrillary Acidic Protein and Tenascin In Chondro-osseous Tumors"Acta Histochemica Cytochemica. 30. 445-453 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] P.Shreatha, Y.Muramatsu et al: "Localization of Ca^<2+>-binding S100 Proteins In epithelial tumors of the skin"Virchows Arch. 432. 53-59 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] R.D.Bhattacharya, M.Mori et al: "Circadian Rhythm of Metallothionein Distribution In Liver, Kidney and Salivary Gland of Rats"Policlinico Sez. Med. (Chronob.). 105. 1-10 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] R.D.Bhattacharya, M.Mori et al: "Circadian Rhythm of Proliferating Cell Nuclear Antigen (PCNA) Immunolocalization In Rat Hepatocyte and the Effect of Mercury Treatment"Policlinico Sez. Med. (Chronob.). 105. 17-30 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Muramatsu, A.Kamegai et al: "Metallothionein Immunoreactivity In Head and Neck Carcinomas ; Special Reference to Clinical Behaviors and Chemotherapiec Responses"Anticancer Research. 20. 1-8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Muramatsu,A., Kamegai,et al.: "Histochemical characteristics of calcium binding S100 proteins and bone morphogenetic proteins in chondro-osseous tumors"Oncology Reports. 4. 849-853 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Muramatsu, A.Kamegai,et al.: "Novel CaィイD12+ィエD1-binding S100 Proteins, Glial Fibrillary Acidic Protein and Tenascin In Chondro-osseous Tumors"Acta Histochemica Cytochemica. 30. 445-453 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] P.Shreatha, Y.Muramatsu,et al.: "Localization of CaィイD12+ィエD1-binding S100 poteins In epithelial tumors of the skin."Virchows Arch. 432. 53-59 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] R.D.Bhattacharya, M.Mori,et al.: "Circadian Rhythm of Metallothionein Distribution In Liver, Kidney and Salivary Gland of Rats."Policlinico Sez.Med.(Chronob). 105. 1-10 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] R.D.Bhattachaya, M.Mori,et al.: "Circadian Rhythm of Proliferating Cell Nuclear Antigen (PCNA) Immunolocalization In Rat Hepatocyte and the Effect of Mercury Treatment."Policlinico Sez.Med.(Chronob). 105. 17-30 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Muramatsu, Y.Hasegawa,et al.: "Mmetallothionein Immunoreactivity In Head and Neck Carcinomas ; Special Reference to Clinical Behaviors and Chemotherapiec Responses."Anticancer Research. 20. 1-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Muramatsu,Y.Hasegawa,et.al: "Metallothionein Immunoreactivity In Head and Neck Carcinomas;Special Reference to Clinical Behaviors and Chemotherapiec Responses"Anticancer Research. 20. 1-8 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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