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Study on Maternal Environmental Factors for Cleft Lip and/or Palate by Transplanting Fertilized Ova

Research Project

Project/Area Number 09672080
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionAichi-Gakuin University

Principal Investigator

NATSUME Nagato  Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Professor, 歯学部・口腔外科学第二講座, 特殊診療科教授 (90183532)

Co-Investigator(Kenkyū-buntansha) NIIMI Teruyuki  Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Assistant Professor, 歯学部・口腔外科学第二講座, 助手 (60291762)
KINOSHITA Hiroyuki  Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Assistant Professor, 歯学部・口腔外科学第二講座, 助手 (70261005)
KAWAI Tsuyoshi  Aichi-Gakuin University, Honorary Professor, 歯学部, 名誉教授 (50064788)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsCleft lip / Cleft palate / CL / P-prone mouse / A / J mouse / C57 / BL mouse / plantation of fertilized ova / maternal environmental factor
Research Abstract

1. We carried out screening in 1998 on the incidence of CL/P. Based on those results we made clear if it is possible to reduce the risk of CL/P appearance by transplantation of fertilized ova along with basic treatments.
2. As we evaluated the following assumptions : How much influence does maternal environment have on CL/P ? If it has much influence, what kind of patients can be protected from CL/P by transplantation of fertilized ova ? Is it possible to prevent CL/P appearance only by basic treatments ?
3. We submitted our study to the Journal "PLASTIC AND RECONSTRUCTIVE SURGERY" and how it is in press.
Collaborator : Jun Kuno (Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Assistant Professor)

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 久野淳: "マウス受精卵移植における口唇,口蓋裂発生に関する実験的研究-口唇,口蓋裂非発生系(C57BL/6系)マウス受精卵の易発生系(A/J系)マウスへの移植-"愛知学院大学歯学会誌. 36(4). 611-616 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jun Kuno, Nagato Natsume, Tsuyoshi Kawai: "Transplantation of Fertilized Ova of CL/P-resistant C57BL/6 Strain Mice to Pseudo-pregnant CL/P-prone A/J Strain Mice"PLASTIC AND RECONSTRUCTIVE SURGERY. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jun Kuno: "Experimental Study on Cleft Lip and/or Palate in Transplantation of Fertilized Ovum Mice, - In the Case of Transplantation of Fertilized Ova of CL/P - Resistant C57BL/6 Strain Mice to Pseudopregnant CL/P-Prone A/J Strain Mice-"The Aichi-Gakuin Journal of Dental Science. 36(4). 611-616 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jun Kuno, Nagato Natsume, Tsuyoshi Kawai: "Transplantation of Fertilized Ova of CL/P-Resistant C57BL/6 Strain Mice to Pseudo-Pregnant CL/P-prone A/J Strain Mice"PLASTIC AND RECONSTRUCTIVE SURGERY. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jun Kuno,Natsume,Tsuyoshi Kawai: "Transplantation of Fertilized Ova CL/P-resistant C57BL/6 Srtain Mice to Pseudo-pregnant CL/P-prone A/J Strain Mice"PACSTIC AND RECONSTRUCTIVE SURGERY. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] 久野,淳: "マウス受精卵移植における口唇,口蓋裂発生に関する実験的研究-口唇,口蓋裂非発生系(C57BL/6系)マウス受精卵の易発生系(A/J系)マウスへの移植-" 愛知学院大学歯学会誌. 36(4). 661-616 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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