| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Research Abstract |
The inhibitory effects of oolong tea extract (0TE) on the caries-inducing properties of mutans streptococci were examined in vitro.GTE reduced the rate of acid production by mutans streptococci accompanied with the retardation of growth rate of mutans streptococci, while the action by chromatographically isolated oolong tea polyphenol (OTF6) was weak.On the other hand, both oolong tea products decreased cell surface hydrophobicity of almost all the oral streptococci examined in the present study, and also induced cellular aggregation of S.mutans, S.oralis, S.sanguis or S.gordonii.In these reactions, OTF6 showed a more pronounced activity than OTE.Furthermore, the oolong tea products inhibited the adherence of mutans streptococci to saliva-coated hydroxyapatite.These results indicate that oolong tea polyphenols may inhibit bacterial colonization on tooth surfaces by reducing the hydrophobicity of mutans streptococci, and OTE may inhibit caries-inducing activity by reducing the rate of acid production.
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