| Project/Area Number |
09672250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
TOBE Takashi Showa Unv., School of Pharmaceutical Sciences, Professor, 薬学部, 教授 (90102368)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | IHRP, / inflammation, / Turpentine oil, / LPS / デキサメサゾン / 急性期蛋白質 / STAT3 / アネキシン |
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| Research Abstract |
The mouse counterpart of human IHRP has been partially purified from mouse serum, and the cDNA come encoding this protein was isolated and characterized. The amino acid sequence of mouse IHRP predicted from the nucleotide sequence of cDNA shows reasonable homology to those of human and pig IHRP.The N-terminal amino acid sequence of partially purified mouse IHRP was completely matched to that predicted from its cDNA.The expression of IHRP in mouse was induced by treatment with turpentine oil or LPS.The induction of IHRP by turpentine was effectively prevented by pretreatment with dexamethasone, but the induction by LPS was not- affected by dexamethasone.
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