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The study for the development of quality-of-life (QOL) assessment methods in cancer treatments ant its application to the practical medicine

Research Project

Project/Area Number 09672309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical sociology
Research InstitutionKAWASAKI MEDICAL SCHOOL

Principal Investigator

SHIMOZUMA Kojiro  Kawasaki Medical School, Medicine, Assistant Professor, 医学部, 講師 (00248254)

Co-Investigator(Kenkyū-buntansha) ICHIHARA Kiyoshi  Kawasaki Medical School, Medicine, Associate Professor, 医学部, 助教授 (10144495)
TANAKA Katsuhiro  Kawasaki Medical School, Medicine, Assistant Professor, 医学部, 講師 (90289174)
SONOO Hiroshi  Kawasaki Medical School, Medicine, Professor, 医学部, 教授 (60136249)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsCancer treatment / Social medicine / Health service research / Outcome assessment / Quality of life (QOL) / Psychooncology / Psychometry / Palliative medicine / アウトガム指標 / Quality of life(QOL) / Ouality of life(QOL)
Research Abstract

1.Translations of the quality-of-life (QOL) questionnaires developed in western countries which were frequently used in many cancer clinical trials and their cross-cultural validation
(1)The translations of the EORTC QLQ-BR23 (breast cancer subscale), FACT-B (breast cancer subscale), and FACT-Taxane were completed. They are used in a phase III ranndomized trials comparing two types of post-surgial adjuvant chemotherapy for breast cancer patient (NSAS-BC).
(2)Semi-fical translations of the FACT-Sp (spiritual well-being), 0 (ovarian cancer), Cx (cervical cancer), C (colorectal cancer), P (pancreas cancer). E (seophageal cancer), ACT (anorexiafcachexia), and ES (estrogen-related symptoms) were completed. They are in the process of pilot-testing.
2.The results of the psychometric properties (acceptability, reliability, validity, and sensitivity) of the two QOL questionnaire measures, that is, EORTC QLQ-C30 and the QOL-ACD, for Japanese cancer patients will be presented in the 35th Annual Meeting of the American Society fo Clinical Oncology (ASCO) and the 7th Annual Meeting of the Japanese Breast Cancer Society in May, 1999. Papers onthese subjects will be submitted in a near future.
3.The results of the detailed assessnents of treatment-related symptoms, psychological destress, and QOL in post-surgical breast cancer patients in Los Angels, and the analyses of predictive factors of their QOL were reported in a paper (Breast Cancer Res and Treat, in press). We geban similar study for Japanese patients.
4.The paper investigating the prognostic significance of QOL scores is in submission.
5.We began the study investigating the risk and and benefit of beast cancer patients receiving adjuvant therapies using Markov decision models in which patients-administered QOL scores assessed by EuroQol, FACT, and Time Trade-off (TTO) will be imputed. The endpoint of the study is cost/QALY (Quality-adjusted life year).

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (92 results)

All Other

All Publications (92 results)

  • [Publications] 下妻晃二郎 他: "進行・再発乳癌治療とQOL-QOLを改善する治療・社会的因子の分析-" 乳癌の臨床. 12(1). 58-67 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 伊波茂道 他: "QOLからみた乳房温存療法と乳房切除術の経時的評価" 乳癌の臨床. 12(1). 58-67 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 園尾博司 他: "インフォームド・コンセント(I・C)I. 臨床の実際 2. 乳癌-1・Cとその後の経過" 臨床科学. 33(4). 425-433 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "癌患者のQOL評価-予後予測因子としての意義" 癌生時研誌. 17(1). 22-28 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiratsuka J. , et al.: "A retrospective study of results of conservative therapy for beast cancer in Japan" Kawasaki Med J. 23(1). 35-42 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田中克浩 他: "食道癌原発の転移性甲状腺癌の一例" 内分泌外科. 14(3). 251-254 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 大塚信昭 他: "甲状腺癌の骨転移診断における^<99m>Te-MIBIシンチグラフィの有用性" 骨転移・病態・診断・治療. 13(1). 23-27 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田中克浩 他: "当科における妊娠・授乳期乳癌の9例" 日本臨床外科医学会雑誌. 58(10). 73-78 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 紅林淳一 他: "Erb B familyを高発現する乳癌細胞株KPL-4の樹立とヒト型抗体Erb B-2 monoclonal抗体による増殖抑制の検討" 乳癌の臨床. 12(4). 644-645 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 片岡 健他: "進行乳癌(病期IIIb)に対する治療-第6回進行・再発乳癌勉強会アンケート集計-" 癌の臨床. 43(12). 1511-1517 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎: "癌疾患と治療-主として乳がん" 癌の悩み電話相談室会誌. 1. 23-38 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎: "QOL評価の意義と問題" 第10回日本臨床腫瘍研究会プログラム・抄録集. 20-21 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu M. , et al.: "Gatric metastasis from breast cancer : A pitfall in gastric biopsy specimens" Pathology International. 48. 240-241 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "癌のQOL治療-II. 治療の実際-4. 癌のQOL治療" 臨床科学. 34(5). 632-640 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katagiri T. , et al.: "High proportion of missense mutations of the BRCAl and RCA2 genes in Japanese beast cancer families" J Hum Genet. 43. 42-48 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "QOL評価 難治疾患の緩和医療 病態の診断と治療目標" Current Therapy. 16(7). 1250-1256 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K. , et al.: "Quality of life(QL)in the year after breast cancer (BC)surgery-What are the predictors?" Proceeding of 34th Annual Meeting of ASCO. 42 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "進行・再発乳癌治療とQOL-QOLを改善する治療・社会的因子の分析-" 緩和治療. 7(1). 47-55 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 園尾博司 他: "サイトカインを指標とした乳癌治療の基礎研究" 外科治療. 79(5). 634-635 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "乳癌をめぐる最近の話題-乳癌患者のQOL" Pharma Medica. 16(8). 89-95 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 紅林淳一 他: "新しい乳癌細胞株の樹立と乳癌の治療につながるTranslational Research" 乳癌の臨床. 13(4). 682-687 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "新薬展望1999乳癌治療剤" 医薬ジャーナル. 35(S-1). 223-229 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "臨床試験におけるQOL評価の意義と問題" 癌と化学療法. 26(2). 183-188 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K. , et al.: "Biochemical markers of bone-turnover in beast cancer patients with bone metastases. A preliminary report" Jpn J Clin Oncol. 29(1). 16-22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 園尾 博司 他: "乳癌の手術-最適化への論点, A. 乳腺切除範囲のpros and cons, 1. 乳房切除術のプラス点" 臨床外科. 54(1). 19-24 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K. , et al.: "Quality of life in the first year after breast cancer surgery : Rehabilitation needs and patterns of recovery." Breast Cancer Res Treat. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maskariec G. , et al.: "A pilot study of mammographic density patterns among Japanese woman." J. Epideminol. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurihara M. , et al.: "Developmennt of quality of life questionnaire in Japan : quality of life assessment of cancer patients receiving chemotherapy." Psychooncology. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎: "Knack and pitfalls, 乳腺外科の要点と盲点, 鎖骨上リンパ節" 文光堂, 2 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎: "乳癌化学療法施行時の留意点. 患者の精神的・社会的機能に影響を及ぼす癌関連因子-告知, インフォームド・コンセント・そしてサポート・グループ" 電通サドラー・アンド・ヘネシー(株), 1 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K. , et al.: "EORTC QLQ BR23 ; The tranlation of the English beast cancer module into Jaonanese" EORTC内部資料, 21 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻晃二郎 他: "がん治療とQualitu of Life 臨床腫瘍学 第2版" 癌と化学療法社, 22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Treatment for advansed or recurrent beast cancer and quality-of-life : Medical and Sociodemographic Factors that improve patients' quality-of-life." Jpn J Breast Cancer. 12(1). 58-67 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Iha S., et al.: "BCT and mastectomy. A comparison of their effects on the quality of life of beast cancer patients." Jpn J Breast Cancer. 12(1). 58-67 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sonoo H., et al.: "Informed consent (IC) - II.Clinical practice 2. Breast Cancer-IC and the process after IC." Risho-Kagaku. 33(4). 425-433 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Prognostic value of quality-of-life scores for cancer patients." Proceeding of The Society For Survival Time Studies on Cancer Patients. 17(1). 22-28 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiratsuka M., et al.: "A retrospective study of results of conservative therapy for breast cancer in Japan." Kawasaki Med J. 23(1). 35-42 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu M., et al.: "Lithium associated autoimmune thyroiditis." J Clin Pathology. 50(2). 172-174 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka K., et al.: "A case of thyroid metastasis from esophageal cancer." Endocrine Surgery. 14(3). 251-254 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Otsuka N., et al.: "The diagnostic usefulness of ^<99m>Tc-MIBI scintigraphy in skeletal metastasis from thyroid cancer." Kotsuten-i Byotai Shindan Chiryo. 13(1). 23-27 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka K., et al.: "Nine case reports of breast cancer patients with pregnancy or lactation." J Jpn Soc Clin Surg. 58(10). 73-78 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurebayashi J., et al.: "Establishment of the breast cancer cell line KPL-4 which highly expresses Erb B family and anti-proliferative effects of human anti-Erb B-2 monoclonal antibody to it." Jpn J Breasr Cancer. 12(4). 644-645 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kataoka K., et al.: "Treatment for advanced (stage IIIb) breast cancer - Questionnaire results in the 6th Meeting of the Advanced or Recurrent Breast Cancer Study Group." Gan-No-Rinsho. 43(12). 1511-1517 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K.: "Cancer and treatments - Breast cancer." Gan No Nayami Denwa Sodan Shitsu Kai Shi. 1. 23-38 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K.: "The significance and the problems of quality-of-life assessment." The Proceeding of the 10th Meeting of the Japanese Society of Clinical Oncology. 20-21 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu M., et al.: "Gastric metastasis from breast cancer : A pitfall in gastric biopsy specimens." Pathology International. 48. 240-241 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Treatment strategies for the quality-of-life of patients with cancer. - II.Treatments - 4.Treatments for breast cancer." Rinsho Kagaku. 34(5). 632-640 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katagiri T., et al.: "High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families." J Hum Genet. 43. 42-48 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Quality-of-life assessments. Palliative medicine for patients with incurable diseases. Diagnosis of the diseases and treatment purposes." Current Therapy. 16(7). 1250-1256 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Quality of life (QL) in the year after breast cancer (BC) surgery - What are the predictors?" Proceeding of 34th Annual Meeting of ASCO. 42a (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Treatment for advanced or recurent breast cancer and quality-of-life : Medical and Sociodemographic Factors that improve pateients' quality-of-life." Kanwa Iryo. 7(1). 47-55 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sonoo H., et al.: "Experimentalresearch targeting cytokines secreted by breast cancer cells." Geka Chiryo. 79(5). 634-635 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Current topics for beast cancer. Quality-of -life in breast cancer patients." Pharma Medica. 16(8). 89-95 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurebayashi J., et al.: "Translational resarch using newly-established human breast cancer cell lines." Jpn J Breast Cancer. 13(4). 682-687 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K.: "Knack and Pitfalls in breast surgery, Supraclavicular lymph node." Bunko-Do. 10-11 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K.: "Factors related to cancer influencing patients' psychosocial functioning. - Notification of cancer, informed consent, and support group. Critical points in chemotherapy for breast cancer patients." Dentsu Sudler and Hennessey Inc.4 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "EORTC QLQ BR23 : The translation of the English breast cancer module into Japanese." EORTC. 1-21 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "The prospect of newdrugs in 1999 - Drugs for breast cancer treatments." Iyaku Journal. 35(S-1). 223-229 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K.: "The significance and the problems of quality-of-life assessment." Jpn J Cancer Chemother. 26(2). 183-188 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Biochemical markers of bone turnover in breast cancer patients with bone metastases - A preliminary report." Jpn J Clin Oncol. 29(1). 16-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sonoo H., et al.: "Breast cancer surgery - Critical points for appropriate therapy, A.pros and cons of the resected area, 1.Benefit from mastectomy." Rinshou Geka. 54(1). 19-24 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Cancer treatment and quality of life. Clinical Oncology 2nd Ed." Gan To Kagaku Ryoho. 1954-1976 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maskariec G., et al.: "A pilot study of mammographic density patterns among Japanese women." J Epidemiol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozuma K., et al.: "Quality of life in the first year after breast cancer surgery : Rehabilitation needs and patterns of recovery." Breast Cancer Res Treat. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurihara M., et al.: "Development of quality of life questionnaire in Japan : quality of life assessment of cancer patients receiving chemotherapy." Psychooncology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 下妻 晃二郎: "QOL評価の意義と問題" 第10回日本臨床腫瘍研究会プログラム・抄録集. 20-21 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimizu M.,et al.: "Gastric metastasis from breast cancer: A pitfall in gastric biopsy specimens" Pathology International. 48. 240-241 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 下妻 晃二郎 他: "癌のQOL治療-II.治療の実際-4.乳癌のQOL治療" 臨床科学. 34・5. 632-640 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Katagiri T.,et al.: "High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families" J Hum Genet. 43. 42-48 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 下妻 晃二郎 他: "QOL評価 難治疾患の緩和医療 病態の診断と治療目標" Current Therapy. 16・7. 1250-1256 (1998)

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  • [Publications] Shimozuma K.,et al.: "Quality of life(QL)in the year after breast cancer(BC)surgery-What are the predictors?" Proceeding of 34^<th> Annual Meeting of ASCO. 1998. 42

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  • [Publications] 下妻 晃二郎 他: "進行・再発乳癌治療とQOL-QOLを改善する治療・社会的因子の分析" 緩和医療. 7・1. 47-55 (1998)

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  • [Publications] 園尾 博司 他: "サイトカインを指標とした乳癌治療の基礎研究" 外科治療. 79・5. 634-635 (1998)

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  • [Publications] 下妻 晃二郎 他: "乳癌をめぐる最近の話題-乳癌患者のQOL-" Pharma Medica. 16・8. 89-95 (1998)

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  • [Publications] 紅林 淳一 他: "新しい乳癌細胞株の樹立と乳癌の治療につながるTranslational Research" 乳癌の臨床. 13・4. 682-687 (1998)

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  • [Publications] 下妻 晃二郎: "癌疾患と治療-主として乳がん-" 癌の悩み電話相談質会誌. 1. 23-38 (1998)

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  • [Publications] 下妻 晃二郎 他: "新薬展望1999 乳癌治療剤" 医薬ジャーナル. 35・S-1. 223-229 (1999)

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  • [Publications] 下妻 晃二郎 他: "臨床試験におけるQOL評価の意義と問題" 癌と化学療法. 26・2. 183-188 (1999)

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  • [Publications] Shimozuma K.,et al.: "Biochemical markers of bone tumover in breast cancer patients with bone metastases.A Preliminary report" Jpn J Clin Oncol. 29・1. 16-22 (1999)

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  • [Publications] 園尾 博司 他: "乳癌の手術-最適化への論点、A.乳腺切断範囲のpros and cons、1.乳房切除術のプラス点" 臨床外科. 54・1. 19-24 (1999)

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  • [Publications] Shimozuma K.,et al.: "Quality of life in the first year after breast cancer surgery:Rehabilitation needs and patterns of recovery" Breast Cancer Res Treat. (in press).

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  • [Publications] Maskariec G.,et al.: "A Pilot Study of mammographic density patterns among Japanese woman" J Epidemiol. (in press).

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  • [Publications] Kurihara M.,et al.: "Development of quality of life questionnaire in Japan:quality of life assessment of cancer patients receiving chemotherapy" Psychooncology. (in press).

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  • [Publications] 下妻 晃二郎: "乳腺外科の要点と盲点、鎖骨上リンパ節" 文光堂, 2 (1998)

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  • [Publications] 下妻 晃二郎: "乳癌化学療法施行時の留意点.患者の精神的・社会的機能に影響を及ぼす癌関連因子-告知、インフォームド・コンセント、そしてサポート・グループ-" 電通サドラー・アンド・ヘネシー(株), 1 (1998)

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  • [Publications] Shimozuma K.,et al.: "EORTC QLO BR23;The translation of the English breast cancer module into Japanese" EORTC内部資料, 21 (1998)

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  • [Publications] 下妻 晃二郎 他: "がん治療とQuality of Life臨床腫瘍学 第2版" 癌と化学療法社, 22 (1999)

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  • [Publications] 下妻 晃二郎: "進行・再発乳癌治療とQOL-QOLを改善する治療・社会的因子の分析-" 乳癌の臨床. 12(1). 58-67 (1997)

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  • [Publications] 園尾 博司: "インフォームド・コンセント(I・C) I.臨床の実際 2.乳癌-I・Cとその後の経過" 臨床科学. 33(4). 425-433 (1997)

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  • [Publications] 下妻 晃二郎: "癌患者のQOL評価-予後予測因子としての意義" 癌生時研誌. 17(1). 22-28 (1997)

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  • [Publications] 田中 克浩: "当科における妊娠・授乳期乳癌の9例" 日本臨床外科医学会雑誌. 58(10). 73-78 (1997)

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  • [Publications] 下妻 晃二郎: "臨床腫瘍学(第2版)がん治療とQOL" 癌と化学療法社(印刷中), (1998)

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Published: 1997-04-01   Modified: 2016-04-21  

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