| Project/Area Number |
09672339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | Toho University |
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Principal Investigator |
MOMOSE Yasunori Toho University, Department of Clinical Pfarmacy, Professor, 薬学部, 教授 (50020813)
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| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | General anesthetics / Membrane fluidity / Ionic Channel / Cell membrane / 膜容量 / 細胞膜 |
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| Research Abstract |
We studied the general anesthetics on membrane capacitance and L-type of Ca^<2+> channel currents in single cardiac myocytes from guinea-pig ventricle. Membrane capacitance (tau)measured by electrophysiological techniques. Halothene, isoflurane and sevoflurane slightly decreased membrane capacitance in single ventricular myocytes. However, thiopental and propofol increased membrane capacitance. Mode of Ca^<2+> channel inhibition by hailothane, isoflurane and sevoflurane are non-use-dependent block, but Thiopental and propofol inhibited Ca^<2+> channel is use-dependent block actions. The results showed that the mechanism of intravenous and inhalation anesthetics action are differ from membrane capacitance. Thiopental and propofol inhibited Ca^<2+> channel through membrane fluidity, however, halothane and isoflurane did not through membrane fluidity.
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